Synthesis and Characterization of Gelatin-Polyvinyl Alcohol Hydrogel for Use in the Release of Fluvoxamine Maleate

In this work, gelatin-polyvinylalcohol hydrogel was prepared using K2S2O8 in aqueous media in the presence of N,N′-methylenebisacrylamide. The gelatin-polyvinylalcohol hydrogel was characterized by FT-IR, SEM and swelling studies. Then, loading and release of fluvoxamine maleate drug was investigated using gelatin-polyvinylalcohol hydrogel. The effects of temperature and pH on the loading and release of fluvoxamine maleate drug in gelatin-polyvinylalcohol hydrogel were studied. FT-IR results confirmed the formation of gelatin and polyvinyl alcohol hydrogel. The results showed that the maximum drug release was obtained at pH = 2 at room temperature after 6 hours with a value of 43.98 ppm. Gelatin-polyvinyl alcohol hydrogel shows about 11 times water absorption at room temperature. The gelatin-polyvinyl alcohol hydrogel is sensitive to pH and temperature and provides controlled release of fluvoxamine maleate in the gastric environment.