The effect of different types of plateletpheresis devices on the quality parameters of the produced platelet units

Plateletpheresis is the collection of platelets from a donor using an apheresis device. There are different types of apheresis devices used for plateletpheresis, and each device can have an impact on the quality of platelet concentrates produced. This review article aims to investigate the effect of plateletpheresis devices on the quality parameters of produced platelet units.

This article reviewed the effects of different apheresis devices on the quality of platelet units by searching keywords in PubMed, Google Scholar, Science Direct, and Scopus databases and used 83 related articles.

To evaluate the quality of the plateletpheresis concentrates, various parameters such as platelet count and yield, WBC and RBC count, platelet aggregation, metabolic activity, platelet activity, and the number of platelets microparticles are evaluated. The platelet counts in platelet concentrates obtained from apheresis devices follow AABB and European standards. In examining the metabolic activity of apheresis platelets in most studies, the level of glucose and pO2 decreased, lactate and pCO2 increased, and pH was within acceptable limits. When comparing platelet aggregation with different agonists, the platelet unit from the Amicus device showed the lowest response, while Trima Accel showed the highest response. Moreover, Amicus reported a higher level of platelet activation and microparticle production, whereas the lowest level of both belonged to Trima Accel.

Conclusions  :

The quality of the plateletpheresis concentrate can be affected by the apheresis device. Although most available devices can provide platelet concentrates in accordance with the existing standards. According to the studies, the Trima Accel device provides a higher quality platelet concentrate than other devices (Haemonetics MCS+, Amicus, Cobe Spectra, Fresenius).