Synthesis, Characterizations and Computational Studies of Metal Ion Complexes Containing Siderphore Analogs and Study of Biosynthesis Siderphores by Pseudomonas Aeruginosaaeruginosa siderphores

In this work, Pseudomonas aeruginosa was used to produce pyocholin as siderphores compound. This biosynthesis to get this type of siderphorses were performed by force these organisms by some metal ions such as Fe3+, Ni2+, Cd2+, and La3+. The produced siderphoreses were extracted and characterized by FTIR and 1H-NMR. Beside this biosynthesis, the analog siderphorses compound (ethyl (Z)-2-(2-(4-bromobenzylidene) hydrazinyl)-4-methylthiazole-5-carboxylate) was synthesized to study its coordination chemistry with Fe3+, Cd2+, and La2+ by complexation processes. This ligand was synthesized and characterized by FTIR spectroscopy, 1H-NMR spectroscopy, and UV-Vis spectrometry. It was found that the synthesized ligand was a bidentate ligand that was expected geometry as octahedral for the Fe (III) and La (III) complexes while tetrahedral geometry for the Ni (II) and Cd (II) complexes. The importance of the study lies in the creation of compounds capable of mimicking the action of bacterial extracts, which can be applied in several fields including toxic, and heavy metal remediation, iron overload diseases, ẞ thalassemia, iron chelators, anti-malarial, biocontrol agent, and cancer. The synthetic compounds were identified also using IR spectroscopy, 1H-NMR, and UV-Vis spectrometry. This work may contribute to open the door to show the probability using siderphores or their analogues to reduce toxic metals levels, pollutants, and waste of crude oil such as cadmium and mercury in Iraq by microbial organisms.