Comparison of Space Closure Rate between Platelet-Rich Plasma (PRP) Injection and Piezocision in Bimaxillary Protrusion Cases

Reducing orthodontic treatment duration is a significant concern for both patients and clinicians, as prolonged treatments can lead to complications like dental caries, root resorption, and decreased patient compliance. This study aims to compare the effectiveness of two minimally invasive techniques—Piezocision and platelet-rich plasma (PRP) injection in accelerating orthodontic tooth movement during space closure in patients with bimaxillary protrusion.

Sixteen patients diagnosed with Angle's Class I bimaxillary protrusion requiring extraction of first premolars were randomly assigned to two groups. Group A (n = 8) underwent Piezocision-assisted orthodontic treatment, while Group B (n = 8) received submucosal PRP injections. In both groups, one side of the maxillary arch served as the experimental side, and the contralateral side served as the control. Measurements of space closure were taken at the initiation of retraction (T0) and after 90 days (T1). Paired t-test, independent t-test, ANOVA and post hoc Tukey test were used for statistical analysis. P-value<0.05 was considered as significant.

There were significant differences in mean difference of space closure between Piezocision experimental group and Piezocision controls(p=0.003);also, there were significant differences between PRP experimental group and PRP controls (p=0.000). In addition, this study did not show any significant differences in the mean difference of space closure between  Piezocision experimental and PRP experimental groups(p=0.252).

Piezocision and submucosal injection of PRP could increase the rate of space closure. There is no difference between Piezocision and PRP in rate of space closure.