Formulation of Sodium Iodide (Na 123I) Oral Capsule

I-123 is a well known radioisotope used for thyroid and its metastases studies. Nowadays this radioisotope produces from Proton bombardment of enriched Xenon 124 by Cyclotron. In this article formulation and quality of the Na 123I has been mentioned. After bombardment, the target was rinsed by distillated water and a clear and colorless acidic solution containing Iodin-123 was obtained. In order to adjust the pH value on 7 and for preparation of Na 123I, a buffer was added to the solution. The results of the quality control were according to the U.S pharmacopoeia, as well as, the high radionuclide purity of 99.99% and radiochemical purity 98%. The solution was added to the capsules that had already filled by the inert powder. Each capsule contained 200 µCi of Na123I, and was sent to be used in hospital.