Differential Responses to Acarbose Between Obese and Non-obese Patients with Type 2 Diabetes Mellitus

To investigate the responses in terms of body weight, glycemic control, metabolic control, and the side effects to acarbose add-on therapy in obese and non-obese type 2 diabetes patients with inadequately controlled by sulfonylureas and metformin. Forty obese (BMI≤ 27) and 80 sex- and age-matched non-obese patients with type 2 diabetes mellitus were enrolled in this 3-month, open-label, case-controlled trial for acarbose add-on therapy. Totally 111 (73 non-obese and 38 obese) patients completed 3-month acarbose add-on therapy. This study adopted a 2-center open-label parallel group design. After a 4-week run-in period, acarbose was added (ti-trated up to 100 mg t.i.d.) to the current sulfony-lureas and metformin combined therapy of sub-jects. Both obese patients (9.3±1.3% vs. 8.3±1.6%, p<0.0001) and non-obese patients (9.4±1.2% vs. 8.4±1.2%, p<0.0001) showed decreased HbA1c af-ter therapy. While obese patients showed a sig-nificant serum alanine aminotransferase (ALT) (61±26 vs. 49±18, p<0.0001) and triglyceride re-duction (242±127 vs. 187±71, p<0.01) after add-on therapy, non-obese patients did not. Neither obese (74.8±9.2 vs. 74.4±9.8 kg, N.S.) nor non-obese patients (61.9±7.9 vs. 61.6±7.7 kg, p=0.0579) show significant decrease in body weight. Both obese patients and non-obese patients showed decreased HbA1c after acarbose therapy. Obese patients had an additional bene-fit of a decrease in their previoulsly elevated ALT and triglyceride levels after acarbose ther-apy.