Relationship between leukocyte differential count and left ventricular systolic dysfunction after acute myocardial infarction

Background and Peripheral leukocytosis is a marker of inflammatory response in the early phase of acoute myocardial infarction(ÂMÏ). Role of peripheral leukocytosis and relative neutrophilia as a risk factor for early development of left ventricular systolic dysfunction (LVSD) is not established. Ôbjective of this study was to examine the relation between peripheral leukocyte differential count and relative neutrophilia with the early development of mild to severe LVSD following ÂMÏ LVSD. The study was designed as a prospective cohort study and included 140 patients with ÂMÏ This was a prospective cohort study done on 140 ÂMÏ patients. Presence and absence of neutrophilia in the patients was determined and LVSD during 7 days of hospital stay in both groups was studied. Moderate to severe LVSD was defined as ejection fraction(ËF) of less than 40% in the first week following ÂMÏ and was detected by echocardiography. Fourty- seven percent of the cohort had a leukocyte count > 11.0 × 109/L on admission and 64% had relative neutrophilia (neutrophiu perecentage>65%). LVSD was detected in 46% of the cohort. Ôf these patients, 65% had leukocytosis and 65% had neutrophilia. Wheras in non LVSD patients leakocytosis and neutrophilia were 32% and 45% respectively. Statistical analysis revealed significant assocition between leukocytosis and the subsequent development of LVSD (odds ratio 3.8, confdence interval of 95% was 2.9-14.7). Çonclusion: Ïn patients with ÂMÏ, peripheral leukocytosis and relative neutrophilia are independently associated with the early development of moderate to severe LVSD. Hene, knowing this condition may help to reduce morbidity and mortality in patients with ÂMJ by treatment interventions.