Adverse Reaction Following Intravenous Immunoglobulin in Primary Immunodeficiency Patients

Background and Intravenous immunoglobulin is used for primary immunodeficiency disorders. There have been some reports that intravenous immunoglobulin causes side effects. The aim of this study was to investigate intravenous immunoglobulin side effects in immunodeficiency patients. The study utilized the data of 29 primary immunodeficiency patients that were referred to allergy and immunology department in Medical Children Center in Tehran. 29 patients having completed record data files in the hospital, were the subjects of this study. Of 29 immune deficiency patients (aged 15 months to 55 years), they were 19 Males (65/51%) and 10(34/48%) Females. Prevalence of disorders include common variable immunodeficiency 16(55/17%), Bruton disease 8(27/58%), hyper IgM 4 (13/79%) and severe combind immunodeficiency 1 (3/44%). Based on the recorded data, the duration of infusion has been 5 months to 15 years. 15 patients had reported side effects (51/72%). 34 infusions from the total of 1,626 infusions accompanied with side effects (2/09%). Most side effects were occurred during 30 minutes onset of infusion and most were caused by rapid infusion. Most side effects were mild reactions (fever, chills and …). Intravenous immunoglobulin is a rather safe drug with mild side effects. With an appropriate technique and proper infusion, these side effects can be reduced.