Preparation of Chitosan Derived from Shrimps Shell of Persian Gulf as a Blood Hemostasis Agent

In this study chitin was extracted from shrimp''s shell of Persian Gulf, using different methods and chitosan is derived from chitin as a microcrystalline powder, which is being named as Persian Gulf chitosan (PGC) with deacetylation degree of 116 % and the viscosity-average molecular weight M.,) of 3.57x10 5. The purpose of this experiment was to evaluate the effectiveness and safety of PGC as a hemostasis agent with surgicalapplication. Results using PGC in sheep carotid punctured hole model showed significant reduction in manual compression time (p<0. 009) of the carotid artery. Comparative results were found in sheep, wherein a created wound in the carotid artery could be sealed relatively quickly and easily. There were no significant differences in time length to hemostasis between heparinized and non-heparinized sheep. This work suggests that PGC is a safe and effective biopolymer to achieve hemostasis.