Determination the Efficacy of Clonidine Premedication on Intraoperative Cardiovascular Stability and Frequency Distribution of Cardiac complication with Placebo after non Cardiac Surgery

Most cardiac ischemic episodes tend to start at the end of surgery and during recovery from anesthesia. α2 adrenergic agonists are effective for this purpose. The aim of this study was to determine the efficacy of oral clonidine as premedication on cardiovascular stability during operation and to prevent cardiovascular complications after surgery.Eighty eight patients enrolled in the study and randomly divided into two groups. The study group received 1mg oral clonidine and the control group received placebo, two hours before anesthesia. Systolic and diastolic blood pressures and heart rate measured and registered in 5 different times. Any change in ECG monitoring during operation and in the recovery room were registered. Also prevalence of postoperative cardiac complications during the first postoperative day was recorded. All data were analyzed with suitable statistical tests. P