Comparing serum leptin and adiponectin levels in controlled and non-controlled type 2 diabetes

It has been demonstrated in recent studies that abnormal levels of adipocytokines may contribute to insulin resistance and type 2 diabetes. The aim of the present study was to compare serum leptin and adiponectin levels in controlled and non-controlled typ 2 diabetes. 117 patients with controlled and non-controlled type 2 diabetes were studied. Patient, were divided into two groups based on their serum HbA1c level; there were 62 patients in the controlled group (6 %< HbA1c≤ 8%) and 55 patients in uncontrolled group (HbA1c>8%). Parameters like age, sex, duration of diabetes and biochemical indicators such as fasting blood sugar, HbA1c, insulin resistance, leptin and adiponectin were determined. Higher leptin and lower adiponectin levels were observed in non-controlled type 2 diabetes. The levels of fasting blood sugar and insulin resistance were significantly higher in the non-controlled group (P<0.05). Leptin and adiponectin may play an important role in the regulation of insulin sensitivity and control of type 2 diabetes.