Prognostic Values of Estrogen and Progesterone Expression Receptors in Ovarian Papillary Serous Carcinoma

Presence of steroid hormone receptors (estrogen and progesterone)in the tumor tissues of various organs correlates with response to therapy and prognosis. Sincetheir role in ovarian cancer is still controversial, in this study we investigated the expression andprognostic value of the estrogen receptor (ER) and progesterone receptors (PR) in ovarian papillaryserous carcinoma (PSC). In this retrospective study we determined the expression of tissue receptorsincluding tissue samples from 36 patients with stage III ovarian PSC by Immunohistochemistrymethod. Then ER and PR expression correlated with clinicopathological parameters and possibleprognostic impact on ovarian PSC were investigated. The correlation between age and survey of patients with ovarian PSC and expressionof steroid receptor was not significant. Although correlation between severity of expression of PRand mortality rate was not meaningful, the relationship between severity of ER expression andmortality rate was significant (P=0.02) The determination of steroid receptor status may offer additional prognosticinformation in ovarian carcinoma (PSC).