Study of Clinical and Histopathological Effects of Ibuprofen after Experimental Wounding of Gum in Rabbit

Ibuprofen can influence the healing processes in soft and hard tissues by inhibiting of COX-Ι and COX- ΙΙ and so prostaglandin synthesis. This study was conducted because accelerating of healing processes in order to reestablishment of physiological functions of tissue after experimental wounding of gum is essential. In this study clinical and histopathological effect of Ibuprofen was evaluated on the process of healing of experimental wounding. We selected 15 New Zealand white rabbits with the same conditions and after numbering، divided to three groups, so that there were 5 rabbits in each group. Then in each group a experimental wounding was created in the right lateral region of mandible with biopsy punch and scalpel and then، after 12 days، clinical and histopathological effects of drug evaluated in high dose (20mg/kg/day) and low dose (1 mg/kg/day) groups compared with control group that received placebo by gavage. A double-blind, placebo controlled method was employed through the study. It was evident that use of this drug had positive effects on healing also that was obvious in clinical and histopathological findings in both of two low dose and high dose groups compared with control group. Also use of high dose of Ibuprofen had better effects on healing process after experimental wounding and the difference was statistically significant (P<0. 01). It was demonstrated that ibuprofen has a dosedependent positive effect on the healing process of gum after experimental wounding and this effect is dosedependent.