The Effect of One Year INH Prophylaxis in Reduction of Clinical TB in HIV-Infected Injecting Drug User Males

Due to increased prevalence of tuberculosis among HIV-infected patients, INH (Isoniazid) chemoprophylaxis has a major impact on the development of clinical tuberculosis. For the evaluation of INH effect on prevention, we used INH, 300 mg daily for 115 available TST (tuberculin skin test) positive HIV-infected patients for twelve months. During three-year follow up, only twelve patients developed tuberculosis which was significantly lower than minimum estimated rate among these patients (>10% per year). We conclude that INH prophylaxis was effective method to prevent clinical tuberculosis among TST positive HIV-infected patients. (Tanaffos 2003; 2(5): 57-61)