BRAIN ABSCESS: MICROBIOLOGICAL, ETIOLOGICAL STUDY AND THERAPEUTIC OUTCOME IN RASOOL AKRAM AND FIROOZGAR HOSPITALS FROM 1998 FOR 3 YEARS

The brain abscess is an uncommon disease that usually occurs after underlying diseases such as: otitis, sinusitis, and … The microbiological profile of this disease has changed in recent years. In addition to surgery, widespread antibiotic regimen is also of importance in treatment of cerebral abscess. The initial antibiotic therapy should be instituted emprically and it should be based on the incidence of various organisms and their sensitivity to antibiotics. The goal of this study is: 1-determination of the underlying diseases in brain abscess for future Preventive strategies and 2-determination of the microbial agent in brain abscess and their sensitivity to conventional and available antibiotic in Iran for better selection of the antibiotic regimen. This descriptive study was done on patients with brain abscess who were hospitalized in Rasool Akram and Firoozgar hospitals from 1998 for 3 years. 26 patients were admitted for 36 months. Direct smear was positive in all patients. Results of culture were positive in 22 cases (84.6%) that only 3 cases had mixed aerobe and anaerobe microorganism. The most common isolated organisms were streptococci (52%) and enterobactriace (36%) that were sensitive to conventional antibiotics. All isolated aerobe bacteria were sensitive to ciprofloxacin. These findings can indicate: 1-The higher incidence of the otitis as an underlying cause of brain abscess in our patients. 2-Inability of our microbiological technique in detection of anaerobe microorganisms. 3-The important role of the direct smear in the primary diagnosis of the brain abscess. 4-Probable role of ciprofloxacin in the treatment of the brain abscess and especially underlying diseases.