A STUDY OF NATURAL OCCURRING ANTICOAGULANT AND ANTIPHOSPHOLIPID ANTIBODIES IN PATIENTS WITH HISTORY OF THROMBOSIS IN TEHRAN

Thrombophilia is a clinical problem throughout the world and it is particularly a major problem in western countries. Factors causing thromboembolic diseases are numerous and they may be inherited or aquired. In order to investigate causes of venous thrombosis. The level of antithrombin (AT), protein C, protein S and the presence of antiphospholipid antibodies (APA) in 300 patients with a history of thrombosis measured. The activity of AT was examined by chromogenic, protein C and protein S by clotting assaies and APA was also detected using ELISA method. A deficiency in one or more of natural anticoagulant determined in 35 out of 156 patients (22.43%) without receiving anticoagulant drugs and 87 out of 144 patients (60.41%) with a recent history of anticoagulant therapy. A significant differences (P<0.01) between the results of these two groups of patients may explain the interference of anticoagulant drugs. In this study a defidiency of AT in 7 cases, protein C in 77 cases, protein S in 39 cases and APA in 47 out of 300 cases were observed. Altogether, the abnormal results of these 4 tests may provide an explanation for thrombosis in (38.46%) of group one patients. If the other causes of thrombosis such as APCR are considered, this percentage will be increased significantly. Therefore this study indicate that some other laboratory tests need to be stablish to define the hypercoagulable state of thrombotic disorders.