Testing Toxicity of Intravitreal Bevacizumab (Avastin) used for the Treatment of Choroidal Neovascularization Associated with Age-Related Macular Degeneration: A Full Field ERG Study
Author(s):
Abstract:
Purpose
To evaluate the toxic retinal effects of intravitreal bevacizumab used for the treatment of exudative age-related macular degeneration (AMD) using Ganzfeld Electroretinography (G-ERG) Methods
In this prospective comparative interventional study, 23 patients with active choroidal neovascularization (CNV) associated with AMD were enrolled. Patients were received intravitreal injections of either 2.5 (12 patients) or 1.25 mg (11 patients) of intravitreal bevacizumab. Patients underwent complete ophthalmic examination including visual acuity testing, and G-ERG, at baseline, at one week, at one month, and at three months after intravitreal bevacizumab. Results
Best corrected visual acuity (BCVA) significantly increased from 1.34±0.59 (logMAR) in preinjection examination to 1.07±0.47 (logMAR) at one month (P=0.01), and 1.03±0.46 (logMAR) at three months (P=0.001). G-ERG did not show any significant change in the waveform parameters following intravitreal injection of bevacizumab. No significant difference was found between the two groups in the amount of change in visual acuity and G-ERG recordings of postinjection measurements. Conclusion
Intravitreal bevacizumab did not appear toxic to the retina based on G-ERG recordingsLanguage:
English
Published:
Journal of Current Ophthalmology, Volume:21 Issue: 3, Sep 2009
Page:
49
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