Extensive Blue Rubber Bleb Nevus Syndrome with Multiple Gastrointestinal Venous Malformations: A Case Report

Blue rubber bleb nevus syndrome is a sporadic disease with widely distributed dark blue papules and nodules and soft skin-colored compressible protuberances (rubber blebs) as well as large vascular malformations. Gasterointestinal lesions are documented by upper endoscopy and colonoscopy; hemorrhages from these lesions create irondeficinecy anemia. Other sites of visceral involvement are less common. We report a 20-year-old male with multiple blue venous nodules on the face, neck, trunk and limbs with occasional bleeding. In addition, he had similar lesions in buccal mucosa and genitalia. Endoscopic examination revealed blue nodular lesions in gastrointestinal tract. Lab tests showed iron deficiency anemia.