LIVER-PROTECTIVE EFFECTS OF HYDDROALCOHOLIC EXTRACT OF ALLIUM HIRTIFULIUM BOISS IN RATS WITH AALLXAN-INDUCED DIABETES MELLITUS

Diabetes mellitus is one of the most common endocrine disorders which is accompanied with many metabolic syndromes. Use of herbal medicines has always been an option to treat a great number of diseases such as diabetes and its complications. In this study the liver-protective effects of hydroalcoholic extract of Allium hirtifolium on liver enzymes level in rats with alloxan-induced diabetes mellitus was investigated. Thirty five male rats were randomly divided into five groups of seven: Group 1: nondiabetic control, Group 2: diabetic control, Group 3: diabetic treated with shallot extract (0.1 g/kg), Group 4: diabetic rats treated with shallot extract (1 g/kg) and Group 5: diabetic treated with glibenclamide (0.6 mg/kg). Using intraperitoneal (IP) injection of Alloxan monohydrate, diabetes mellitus was induced in rats. Diabetic rats were treated with IP injection for 4 weeks. At the end of the experimental period fasting blood samples were collected. Statistical analysis of the data indicated hydroalcoholic extract of shallot can significantly decrease serum contents of Liver enzymes (ALP, AST, ALT) in treated groups. In most cases, the effectiveness of the extract on reduction of these enzymes is more than glibenclamide. Antioxidant compounds in the extract may recover liver damages caused by free radicals in diabetic rats.