Comparing ceftriaxone and cefazolin for treatment of adult acute pyelonephritis; A clinical trial

Urinary tract infection (UTI) is a major health concern worldwide. The present study was aimed to compare drug resistance to ceftriaxone and cefazolin in adult patients with acute pyelonephritis. Patients and For this clinical trial، patients with fever plus either dysuria، frequency، flank pain or flank tenderness were enrolled. Having performed urinalysis (U/A)، urine culture (U/C) and antibiogram، they were randomly assigned in two groups: ceftriaxone 1gr twice a day or cefazolin 1gr trice a day. Three days later، urine was re-evaluated and patients were categorized as clinical and microbiological responders. Chi-square test and Fisher’s exact tests were used، when appropriate. Statistical significance was defined as p