Comparison of the effect of non-surgical periodontal therapy with and without systemic doxycycline on the health of periodontium and HbA1c in type 2 diabetic patients without good glycemic control

Background and aims. The aim of the present study was to evaluate the result of full scaling and root planning with and without systemic administration of doxycycline on periodontium and metabolic control in type 2 diabetes mellitus (DM) patients.Materials and methods. Thirty patients with type 2 DM with poor glycemic control were selected and randomly assigned into two groups. Case group received scaling and root planning and doxycycline (SRP + Doxy) and control group received only SRP. Probing pocket depth (PD) and bleeding on probing (BOP) as the most important indicators for periodontal health were recorded at baseline, 3- and 6-month follow-up. Fasting blood sugar (FBS), glycated hemoglobin (HbA1c), total cholesterol (TC), and triglyceride (TG) were analyzed before and after periodontal treatments.Results. A statistically significant reduction was observed for PD and BOP for the treatment groups. HbA1c levels in SRP group decreased more significantly than SRP + Doxy group (9.15 ± 0.76 to 7.73 ± 1.41% and from 8.41 ± 0.49 to 7.88 ± 1.77%, respectively).Conclusion. Non-surgical periodontal treatment is associated with improved periodontal health and glycated control in DM type 2 patients and could be considered as an important part of the diabetic patient care.