The Effect of Cumin Seed Extracts against Herpes Simplex Virus Type 1 in Vero Cell Culture

Message:
Abstract:
Background
Central post-stroke pain (CPSP) is a distressing pain syndrome, sometimes become refractory to the conventional pain managements. Anticonvulsants have been used to alleviate different central pains. Lamotrigine is a novel anticonvulsant and its proper dosage and its efficacy have not been well studied yet. The aim of this study was to evaluate the effect of 100 mg lamotrigine on refractory form of CPSP.
Methods
The medical files of 17 patients with CPSP who had not responded to the other drugs and were treated with lamotrigine were studied. Using Brief Pain Inventory, pain, sleep and mood were assessed before, and after 8 and 24 weeks of treatment.
Results
After 24 weeks, 70.5 % of the patients responded to lamotrigine, and there was an improvement of 2.41 in the mean score of average pain (P=0.001).
Conclusion
Lamotrigine 100 mg daily was effective in the treatment of refractory CPSP, and might be prescribed before planning for more aggressive surgical managements.
Language:
English
Published:
Iranian Journal of Medical Sciences, Volume:35 Issue: 4, Dec 2010
Page:
304
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