Measurement and Correlation of Ibuprofen in Supercritical Carbon Dioxide Using Stryjek and Vera EOS

Ibuprofen solubility in supercritical carbon dioxide was measured using a dynamicapparatus at a pressure between 80 and 140 bars at three different temperatures,308.15, 313.15 and 318.15 K. The mole fraction of Ibuprofen in fluid phase was in therange of 0.015 × 10-3 - 3.261 × 10-3 at the mentioned operational condition. ModifiedMendez-Santiago and Teja equation were used to check the consistency of theexperimental data. Results were correlated using the Stryjek and Vera equation of statewith the van der Waals 1-parameter (vdW1) and 2-parameters (vdW2) mixing andcombining rules. Interaction parameters along with the percentage of the averageabsolute relative deviation (%AARD) were displayed. Also, the Lydersen groupcontribution methods were used for predicting the physicochemical and criticalproperties of the Ibuprofen.