Anti nociceptive and anti-inflammatory effects of aerial parts of Gundelia tournefortii L. on NMRI male mice

Gundelia tournefortii is traditionally used to relieve pain and inflammation. The aim of this study was to evaluate the antinociceptive and anti- inflammatory effects of Gundelia tournefortii in mice. After determining the Lethal Dose (LD50) of the total extract of Gundelia tournefortii, its different doses of total extract was injected in mice (IP) and then antinociceptive and anti-inflammatory effects were determined by formalin and xylene tests. The result of this study demonstrated that the total extract of Gundelia tournefortii in doses of 0.3, 0.6, 1.2 and 2.4 g/kg induced significant antinociceptive and anti-inflammatory effects compared to the control group. The most effective dose of extract was found at 2.4 g/kg. LD50 was obtained at 6.28 g/kg of animal weight. The total extract of Gundelia tournefortii significantly reduces the nociception and inflammation.