Correlation between the Level of Creatinine, Serum Cardiac Troponines and Left Ventricle Function Tests in Patients with Chronic Renal Diseases without Acute Coronary Syndrome

The aim of this study was to survey the relationship between the level of creatinine, cardiac troponins serum and the function of the left ventricle in patients with kidney insufficiency, without acute coronary syndrome.

The sample was 150 patients with nondialysis chronic kidney disease without acute coronary syndrome, hospitalized at Imam Khomeini Center through 2008-2009. All the patients had serum creatinine (cr) 1.5mg or greater and no symptoms of acute coronary syndrome in the first month. Serum Cr and troponin T and I were measured in blood samples and patients left ventricular function (LVEF) were estimated by echocardiography. Then based on the objectives, the findings were analyzed with SPSS soft ware.

Serum troponin T levels were significantly higher in patients with greater Cr levels but there was no significant relationship between troponin I and Cr levels. Patients with greater degrees of LV dysfunction had significantly upper levels of troponin T(P=0.0001). In this category, patients with diabetes, old age, cigarette smokers, greater levels of Cr, advanced stages of chronic kidney disease and greater degrees of LV dysfunction showed significantly higher levels of troponin T(P =0.0001).

To identify chronic kidney disease patients at increased risk for cardiovascular events, serum troponin T can be used. In high-risk patients, the evaluation for cardiovascular diseases could be done earlier in the course of chronic kidney disease.