Giant Cell Glioblastoma - A Rare Pediatric Cerebral Neoplasm

Giant cell glioblastoma is an extremely rare variant of Glioblastoma (WHO grade IV) which is characterized by a predominance of bizarre, multinucleated giant cells. These tumors comprise of 0.8% of brain tumors and up to 5% of glioblastomas. In pediatric age group, these tumors are still uncommon with only around 53 published cases since 1952. Here, we report a case of a 12- year old female patient who presented in outpatient clinic with a short period history of headache and seizures. A CT scan showed a large right sided frontal space occupying lesion with areas of calcification. The patient was operated and subsequent histopathology revealed a high-grade astrocytic tumor with increased cellularity, atypical mitosis, bizarre multinucleated giant cells along with large areas of ischemic necrosis and calcification. A diagnosis of Giant cell glioblastoma (WHO Grade IV) was made. The patient was symptomatically well at 3-month follow-up.