Comparative Study of Pharmaceutical Effect and Therapeutic To-lerance of Amoxicillin and Cefixime in Children with Acute Otitis Media

Proper and on time treatment of acute otitis media could prevent complications. Antibiotic therapy has the principal role in treatment. In recent years, modalities of treatment are increasingly become evidence based. This study was done to determine and compare the efficacy and therapeutic tolerance of amoxicillin and cefixime in children with acute otitis media.

In a randomized clinical trial, 200 more than 2 years children with acute otitis media were enrolled by simple convenient method. They were randomly divided in two groups, treated with amoxicillin or cefixime. Data were gathered by interview, observation, and tympanometery testand were analyzed via SPSS software.

The frequency of signs of acute otitis media after completing of drug therapy was not significantly different between the two groups. In the other words, the cure rate in two groups was equal. In regard to drug tolerance, there was not any significant adverse drug reaction in two groups but, only one patient among the amoxicillin group suffered from mild diarrhea.

Based on findings of the study, we can say that both drugs have the same efficacy and tolerability. So in children have difficulty with oral drugs coping, an alternative antibiotic with longer duration of half life such as cefixime can be the first line drug for treatment of acute otitis media.