Reduced sensitivity of staphylococcus aureus to vancomycin

Staphylococcus aureus is one of the most common causes of infections in hospitals and vancomycin is used for the treatment of methicillin resistant S, aureus infections. Therefore, imergence of Staphylococcus aureus with reduced sensitivity to vancomycin is a serious problem. The aim of this study was to investigate the prevalence of Staphylococcus aureus with reduced susceptibility to Vancomycin and to determine of their antibiogram patterns. This descriptive cross-sectional study was performed in a period of one year and 104 strains of S.aureus were determined on the basis of gram staining, susceptibility to Novobiocin, production of catalase, coagulase and DNase. Susceptibility pattern to Vancomycin and others antibiotics by disk diffusion and MICs were determined by agar dilution methods, according to CLSI. The highest sensitivity rates were observed to vancomycin (96.2%) chloramphenicol (88.5%), and rifampicin (81.7%). Prevalence of MRSA was 40.4%. The rate of VISA was 4 (3.8%). We recommend that clinicians must be aware of management of patients who are colonized or infected with VISA and VRSA and early detection of VISA and VRSA isolates should be considered at the earliest.