Formulation and prepration of cefuroxime axetil tablets by direct compression

Cefuroxime axetil is a broad-spectrum second- generation cephalosporin which has activity against gram-positive and gram-negative microorganisms. The aim of the present study is designing and formulation of cefuroxime axetil tablets (250 mg) using direct compressiontechnique which is nowadays considered as a cost effective and simple method of tablet manufacturing. In order to obtain the optimized products, different formulations were designed using Cefuroxime axetil and 6 different excipients (lactose, avicel, aerosol, PVP,croscarmellose sodium (Ac-Di-Sol) and Magnesium stearate). After measuring the powder flow rate and hardness of formulation, five formulations were selected for dissolution test. All the selected formulations having accepted flow and hardness, released more than 60% drug in 30 minutes. It is concluded that using appropriate statistical methods and direct compression, suitable formulations of Cefuroxime axetil could be reached.