Effects of β -hydroxy- β -methylbutyrate on kidney parameters and body composition in untrained males after 8 weeks combination resistance training

It has not been precisely studied for its harmless effects of β-hydroxy β-methylbutyrate (HMB) in human yet and just a few studies have been done on its effects of the indices on the health in animal. The purpose of this study was to examine the effects of 8 weeks resistance training and consumption HMB (β-hydroxy β-methylbutyrate) on kidney parameters and body composition of untrained males. In this clinical trial, 24 untrained male students were selected and randomly divided to two groups. Group one took placebo (control n=14) and group two received HMB (case, n=10). The subjects were trained for 8 weeks, 3 sessions every week. Blood and urine samples were taken fasting, one day before and 2 days after resistant training. Creatinine and urea were measured and glomerular filtration rate (GFR) was also calculated. The weight and body composition of the subjects were analyzed by the body composition analyzer and the strength of lower and upper limbs were measured by the seat press and squat, respectively. Dependent and independent student t-test were used for statistical analysis. Supplemental group had significant increase in lean body mass (P=0.002) and significant decrease (P=0.006) in fat mass. In addition, HMB group had more increase in strength of one repetition maximum than control group. Furthermore, HMB supplementation caused significant decrease (P=0.036) in blood urea nitrogen in urine. HMB supplement had no effects on blood urea, blood creatinine, urine creatinine and GFR. Consumtion of HMB supplement causes an increase in the lean body mass and the strength of one maximum repetition and decrease in body fat of untrained subjects. In addition consumption of HMB for 8 weeks has no side effect on renal function tests.