Baker.s asthma; Offer probable mechanism of the efficacy of Saccharomyces cerevisiae in cause and induce baker.s asthma

Asthma is a complex genetic disorder that displays various phenotypes، and this is attributed to the interactions among many genes and environmental factors، that considered in terms of its hallmarks of reversible airflow obstruction، non-specific bronchial hyper reactivity and chronic airway inflammation. T-lymphocytes are known to play a central role in the inflammatory process of bronchial asthma. However، the molecular mediators responsible for clinical symptoms due to fungal exposure in individuals with asthma are still not known، correlation between fungal exposure and aggravation of inflammatory symptoms in asthmatic individuals is well documented in the literature. Clinical symptoms in non-allergic inflammation due to many types of microbial exposure are characterized by high systemic production of pro-inflammatory cytokines such as tumor necrosis factor α. Recently، a role for the plasma protein mannan-binding lectin has been proposed in individuals with severe asthmatic disease، although little is known about its role in those with mild and untreated asthma، mannan-binding lectin has been reported to modulate inflammatory cytokine production، but the mechanisms are not known. We speculate thatreduced tumour necrosis factor α production in monocytes from asthmatic subjects after fungal cell wall mannan stimulation could partly be influenced by plasma components such as mannan-binding lectin.