Journal of Skin and Stem Cell
Volume:2 Issue: 1, Mar 2015

Angiolymphoid hyperplasia with eosinophilia (ALHE) is a benign slow-growing vascular proliferation characterized by dome-shaped violaceous papules or nodules. Although it is usually found in the head and neck, it is reported in liver, orbit, spleen, palate, bone, heart, blood vessels, parotid gland, and colon.

We reported a 36-year-old man with ALHE lesion on penis and discussed the clinical and histopathological features.

When we have any dermal or subcutaneous lesion on genitalia, we can consider ALHE in differential diagnosis.

Eccrine poroma is a benign neoplasm thought to derived from Eccrine sweat glands. Recently, studies have shown wide distribution of Eccrine poroma, including acral, face, and abdomen forms.

We reported a 65-years-old woman with rapidly growing 5-cm ulcerative Eccrine poroma with active bleeding since one year prior to presentation.

Although rapid growth and bleeding can be related to malignancy and biopsy is necessary to be performed, benign lesions can present with mentioned symptoms. Physicians should be aware that benign poroma can present as an ulcerative and large neoplasm.

A keloid is dysregulated fibroproliferative scar tissue in response to skin injuries, which extends beyond the wound margin. Since it has a poor response to treatment, variable therapies are used. Current therapies of keloid include intralesional corticosteroid injection, cryotherapy and various laser therapies, silicone gel sheets (pressure therapy), interferon-α-2b, 5-fluoruracil or bleomycine administration, excision followed by low dose radiation or topical imiquimod.

The aim of this study was to compare the efficacy and safety of “intralesional triamcinolone with cryotherapy” and “Intralesional verapamil with cryotherapy”.
Patients and

Eighty patients (42 females and 38 males, aged 11 - 40 years) were allocated to receive one of the four treatment methods. Group 1: Intralesional triamcinolone with cryotherapy. Group 2: Intralesional verapamil with cryotherapy. Group 3: Intralesional verapamil. Group 4: Cryotherapy. Improvement of healing was measured using modified Vancouver scar scale and centimeter scale.

There was a real faster response in the first group; while groups 3 and 4 had the slowest responses to treatment. Rates of responsiveness seemed to have no significant difference between the groups, but side effects were significantly much frequent in the first group.

Intralesional triamcinolone acetonide with cryotherapy showed the most efficacies with more adverse effects, but intralesional verapamil with cryotherapy showed good efficacy with less adverse effects. Hence, it is a suitable alternative in the treatment of keloids.

raditional persian medicine (TPM) is an ancient temperamental medicine with a rich literature about aging mechanism. Temperament has an important function in maintaining the ideal healthy status of human body. Aging process and skin aging could be postponed by applying herbal medicine and some specific traditional rules.

  The aim of this review study was gathering and discussing the mechanism of whole body aging and skin aging from perspective of TPM and introducing remedies to prevent it. Skin aging is caused by external and internal factors. According to TPM, loss of fat and water content in different skin layers is the main cause of skin aging and it could be avoided by considering simple essential commands.

Skin aging begins with whole body aging process and entire body gets cold and dry in elderly. Wrinkle formation is highly associated with loss of “skin natural moisture”. In the management, specific food supplements, simple massage therapy as well as herbal drugs were suggested. The current investigation was performed to show the knowledge of ancient Iranian scientists on aging process and related interventions.

Reported herbal drugs might be beneficial for further studies for the management of skin aging and aging process.