Tanaffos Respiration Journal
Volume:19 Issue: 3, Summer 2020

Obstructive sleep apnea syndrome (OSAS) is a disorder with high prevalence among adults and is an independent risk factor for various diseases, especially those affecting the central nervous system (CNS). Continuous positive airway pressure (CPAP) is usually the optimal choice of treatment for OSAS. Alzheimer’s disease (AD) is a neurodegenerative disease affecting a large proportion of the elderly population. The purpose of this study was to collect information concerning the two pathological entities and investigate the effectiveness of CPAP in the treatment of AD.

In this review, Twenty articles were found concerning OSAS and AD, of which one article was about treatment with donepezil and seven articles considered treatment with CPAP.

Serious OSAS and short sleep duration are associated with a high risk of developing dementia. Respiratory distress during sleep is associated with developing mild cognitive impairment at younger ages. The cerebrovascular damage of AD patients is correlated with the severity of OSAS. Lower cerebrospinal fluid levels are associated with memory disturbances and oxygen saturation parameters in patients with OSAS-AD. Continuous use of CPAP is related to the delayed onset of cognitive impairment and is suggested as an effective method of protecting cognitive function, depression, sleep quality and architecture, and daytime sleepiness in AD patients with good compliance. Treatment of CPAP patients with OSAS-AD is suggested as an effective method of protecting cognitive function.

Clinicians dealing with AD patients should consider CPAP treatment when OSAS coexists.

An initial evaluation of non-small cell lung cancer (NSCLC) patients with 18F- fluorodeoxyglucose (FDG) positron emission tomography/computed tomography (PET/CT) scan can modify treatment planning. We investigated the clinical significance of FDG PET/CT quantitative parameters (QPs) in NSCLC patients. We included 125 NSCLC patients for initial staging FDG PET/CT scan. The primary tumor (T), regional lymph node metastases (N), and distant metastases (M) were evaluated on FDG PET/CT images. QPs, including standard uptake value (SUVmax), metabolic tumor volume (MTV), and total lesion glycolysis (TLG) were calculated separately for each T, N, and M lesion and also for the whole body. Statistical analysis through SPSS version 22 was used to evaluate the clinical significance of PET/CT QPs concerning primary tumor pathology characteristics, initial tumor stage, and patient’s prognosis. We followed the patients for 19.28 (±11.42) months. Considering primary tumor pathology, there was a significant difference in FDG PET/CT QPs, including primary tumor SUVmax (p=0.00), metastases SUVmax (p=0.014), whole-body MTV (p=0.045), and whole-body TLG (p=0.002). There was also a significant difference in QPs, including primary tumor SUVmax (p=0.00) and regional lymph node metastases SUVmax (p=0.048) when accounting for tumor initial stage. There was a significant prognostic value for the whole-body TLG (p=0.01) and a cut-off point of 568 was reached to differentiate better versus worse survival outcome. We demonstrated a statistically significant difference in FDG PET/CT QPs when accounting for primary NSCLC pathology characteristics and initial stage, as well as patient’s prognosis, and recommend incorporating QP values into clinical PET/CT reports.

This study was done to determine the role of common variables, including age, gender, body mass index (BMI), rhinosinusitis, and smoking among a group of asthmatic and severe asthmatic patients in 2016.

This retrospective study was carried out from mid-June to the end of September 2016. Of 678 patients with asthma referred to private asthma clinics in Tehran, 163 subjects were selected. Severe asthma (SA) cases were diagnosed according to the SA definition (severe shortness of breath, chest tightness or pain, and coughing or wheezing, low peak expiratory flow (PEF) using a peak flow meter, and more than two days of wheezing and coughing per week). Patients with the presence of concomitant diseases, such as gastroesophageal reflux disease, sleep apnea, hypo- and hyperthyroidism, as well as users of nonsteroidal anti-inflammatory drugs (NSAIDs) were excluded.According to the signs and symptoms and classic criteria of asthma, the subjects with SA were assigned to the case group and subjects with asthma to the control group. Besides, general information, including age, gender, BMI, smoking history, and the presence of Rhinosinusitis was collected.

Of 163 subjects, 92 patients (56.4%) were in the control, and 71 patients (43.6%) in the case group. The rate of SA among 678 patients was 10.47%. The mean age of the case group was 49.08 ±11.66 and the control group was 50.05 ±15.65 years. There was a significant difference in BMI between the case and control groups (p=0.034), especially among females in the case group (p=0.001). BMI was significantly higher in females than in males (p=0.002). Also, smoking status was not significant between the case and control groups (p=0.751). Rhinosinusitis was significantly higher in the case groups compared with the control groups (p= .014).

Rhinosinusitis was higher in SA patients (case group). SA was more observed among females than males and those who were more overweight. It seems that rhinosinusitis and obesity are more important risk factors.  Moreover, obese female patients require more serious attention.

The current study was done to evaluate the validity and reliability of the Vitalograph COPD-6 portable device for detecting chronic obstructive pulmonary disease (COPD) in high-risk individuals in Iran.
This research was a cross-sectional descriptive study. Forced expiratory volume in one second (FEV1), forced vital capacity (FVC), and FEV1/FVC using standard spirometer and FEV1, FEV6, and FEV1/FEV6 with COPD- 6 device were measured and recorded. Descriptive analysis was done.
19 of 122 patients (15.6%) were diagnosed with COPD. The COPD-6  had an acceptable performance for detecting COPD  as assessed by the area under the receiver operating characteristic (ROC) curve (0.72 ; 95% CI: 0.42-0.86),  with an average sensitivity of  84%  and specificity of 98%, positive predictive value of 89%, and negative predictive value of 97%. The positive likelihood ratio resulted was 42 and the negative likelihood ratio was 0.16.
COPD-6 is a validate and reliable device for detecting COPD in non-specialized health care settings and the best cut-off point for FEV1/FEV6 ratio is  0.72.

The present study was done to compare serum heart type-fatty acid-binding protein (H-FABP) levels in patients with stable chronic obstructive pulmonary disease (COPD) and healthy subjects and address the correlation of this marker with airflow limitation and health-related quality of life using the COPD assessment test (CAT).

In this cross-sectional study, we measured serum H-FABP levels in 50 patients with stable COPD and 34 healthy controls and compared them in terms of smoking history, airflow limitation according to the Global Initiative for Chronic Obstructive Lung Disease (GOLD) criteria, and CAT score. We also tested the association between serum H-FABP level and the COPD patients’ clinical parameters. For statistical analysis, we used the Student's t-test, ANOVA, and Pearson’s (or Spearman’s rank -order) correlation test.

Serum H-FABP level increased in the COPD patients compared with the control group (P<0.01). Although there   was no association between serum H-FABP levels and disease severity based on the GOLD criteria, FABP levels increased in the subjects with a history of smoking in compared with the non-smoker control subjects (P< 0.01). In addition, there was a significant positive correlation between serum H-FABP level and smoking history (r = 0.367, P = 0.001).

The serum H-FABP level increased in both the stable COPD patients and healthy subjects with smoking history. However, no   correlation was found between serum H-FABP and the severity of airflow limitation based on the GOLD criteria.  Based on the results, it is unclear whether the H-FABP level is a causative factor in COPD patients or healthy smokers.

Hormonal changes in women, especially at menopausal transition, may have significant consequences on respiratory function. This issue in asthmatic patients is more frequent, more severe, and less controlled after menopause. Tunisian data regarding this issue are limited; therefore, we assessed the clinical and functional particularities of asthma at menopausal transition.
This descriptive-analytical study was performed for two years (2016-2017) on 82 asthmatic women followed up in the pulmonology department of Charles Nicolle hospital of Tunis. According to hormonal status, two groups were defined: G1 (menopausal patients) and G2 (non-menopausal patients). Asthma control and severity of asthma as well as other variables including gender, age, body mass index (BMI), comorbidities, allergenic status, spirometry results, health care use in the past 12 months, and prescribed medications were evaluated.
The mean age of patients was 50 years and half of them (60%) were menopausal women. Allergy was the most common cause of asthma (82%). A mean of 2.3 exacerbations per patient was recorded. Asthma was well controlled in 58% of patients and was moderate to severe in 80% of them. Menopausal asthmatic women had more comorbidities (p=0.006), particularly arterial hypertension (p<0.0001). Atopy was more common in non-menopausal women and they were all allergic (p=0.01). Menopausal asthmatic patients had more airflow obstruction with lower forced expiratory volume 1 and forced vital capacity (p<0.0001). They also had more exacerbations (p<0.0001) with lower PaO2 (p=0.006). Univariate analysis showed that menopause was a predictive factor of severity (p=0.01) and bad control of asthma (p=0.03). Multivariate analysis confirmed that menopause was a predictor of severity (p=0.01; OR=5.02, IC [1.36-18.46]) but not control of asthma despite the tendency to significance (p=0.07).
Our results confirm that menopause is a factor influencing the control and severity of asthma.

Ventilator-associated pneumonia (VAP) is the most common infection in intensive care units (ICUs), with the highest mortality rate of all hospital-acquired infections. This study aimed to improve the quality of VAP control in the ICU of a university-affiliated teaching hospital in Kouhdasht, Iran.

This action research was conducted during 2016-2018. The survey data of 18 participants, who were included in the study using the non-probability sampling method, were evaluated. Qualitative data were analyzed using Graneheim and Lundman’s qualitative content analysis, and descriptive indices and t-test were measured to analyze quantitative data. Finally, the qualitative and quantitative data were integrated.This research was developed and implemented in four stages, including assessment and identification of priorities for improvement, design of action plans, implementation of action plans, and reassessment. Data were collected by analyzing 540 performance observations, 55 interviews, six focused group discussions, and two steering group discussions.

The mean scores of VAP control before and after implementing the action plans were 259.33±21.64 and 395.16±13.90, respectively (P<0.001). The qualitative findings indicated that the low quality of the personnel’s working life and poor organizational culture were the main barriers to the quality improvement of VAP control. Improvement was achieved after implementing the action plans for enhancing the nurses' quality of working life and realization of their professional identity.

The results of this study suggested that effective approaches, such as personnel empowerment, improvement of environmental conditions, and provision of facilities and equipment can improve the quality of VAP control in ICUs.

In elderly patients, the management of the endotracheal tube after coronary artery bypass graft (CABG) can be challenging because they often have complex comorbidities. This study was done to determine endotracheal tube duration in elderly patients after CABG.
This retrospective study was conducted on 397 patients aged over 65 years under mechanical ventilation after CABG. Patients in two groups of endotracheal tube duration of less than 8 h and more than 8 h were compared. Medical records were used for data gathering. Descriptive statistics, Mann-Whitney U, Kruskal-Wallis test, and logistic regression model were used for data analysis.
Endotracheal tube duration was 9.9± 5.89 h in elderly patients. According to the results of the Mann-Whitney U test, there was a significant difference between the two groups in terms of the history of smoking (p = 0.023), history of diabetes (p= 0.062), left ventricular ejection fraction (p= 0.028), and type of operation in terms of emergency and non-emergency (p= 0.069). The logistic regression model showed predictive variables of the endotracheal tube duration after CABG in elderly patients over 65 years, including the history of smoking (1.179- 4.543, CI: 95%,  β=0.839, and , p=0.015), history of myocardial infarction (0.188- 1.019, CI: 95%, p= 0.055, β= -0.827), and the left ventricular ejection fraction less than 50% (0.202-0752, CI: 95%, p= 0.005, β= -0.943).
Considering the predictive factors, the duration of the postoperative endotracheal tube can play an important role in the careful care of elderly patients after CABG.

The initiation age and prevalence of smoking water-pipe are two important parameters for establishing preventive policies. Thus, the present study was conducted to introduce a new approach for estimating and evaluating the effect of demographic variables on the initiation age and prevalence of smoking water-pipe.
The STEPwise approach for non-communicable disease risk factors surveillance (STEPS) 2011 data were used and daily smokers and non-smokers with the age range of 16 to 70 years were included in the study. A survival mixture cure rate model with doubly censoring was used.
Totally, 9764 individuals were enrolled in the study. No significant association was observed between the initiation age and gender (HR=1.07, 95% CI: 0.76, 1.58), whereas there was a significant difference between initiation age and area of residence (HR=0.62, 95% CI: 0.44, 0.88). The mean age of starting smoking was 25.82 years (95% CI: 24.13, 27.63). The odds of smoking in men were higher than in women (OR=2.34, 95% CI: 1.79, 3.7). The prevalence of smoking had a significant association with socioeconomic status (OR=0.84, 95% CI: 0.72, 0.97), but no association with the level of education (OR=1.06, 95% CI: 0.97, 1.15) and place of residence (OR=1.2, 95% CI: 0.93, 1.57) was found. The estimated prevalence of smoking water-pipe in total, men, and women was 4.8% (95% CI: 4.19%, 5.51%), 7.77% (95% CI: 6.76%, 8.86%), and 3.47% (95% CI: 2.8%, 4.25%).
A new statistical methodology was applied to estimate and evaluate the effect of demographic variables on the initiation age and prevalence of water-pipe smoking.

Intensive care unit acquired weakness (ICUAW) is a known complication in ICU patients, especially in those with severe underlying diseases. The cause and pathogenesis of ICUAW are still unknown. This study examined the incidence rate of ICUAW in intensive care units (ICUs) of the Masih-Daneshvari Hospital.
This descriptive-comparative study was conducted on 160 patients admitted in the ICUs, including an acute respiratory infectious ICU (TB-ICU) and medical ICU. The total number of patients was 80 in each of the ICUs.  Demographic information was obtained from the patients after the initial examination and Medical Research Council (MRC) score was done on daily basis. EMG was performed on the 2nd and 8th days of the admission. ICUAW diagnosis was used in cases with MRC scores under 48.
Among the patients, 68.6% were male and the mean age was 59.13±18. 68 years. The final outcomes were 48.4% mortality and 51.6% discharge, which were 41% and 59% in the TB-ICU and 56.7% and 43.3% in the medical ICU, respectively. By defining electromyography as the gold standard, the sensitivity and specificity of ICUAW diagnosis based on the MRC score definition were about 70% and 83%, respectively. The comparison ICUAW patients in the two ICUs in terms of mortality showed no significant difference between them.
It is concluded that nearly half of ICU-admitted patients develop ICUAW that causes a higher mortality rate. Therefore, new plans should be developed to reduce the rate of ICUAW and subsequent death, as well as other possible morbidities.

Caffeic acid phenethyl ester (CAPE) is one of the major components of honeybee propolis and its structure is similar to flavonoids. CAPE has been shown to possess anti-inflammatory, immunomodulatory, and antioxidant properties. Despite a wide range of biological activities of CAPE, detailed biochemical mechanisms of its action are poorly described. The aim of the present study was to investigate the in vitro effect of CAPE on isolated rat trachea.

A 20 mm long portion of rat tracheal spiral was submerged in 20 ml Krebs solution in an isolated organ bath at 37°C. Changes in tracheal contractility in response to the application of agonist agents were measured using an isometric transducer connected to a Harvard polygraph.

Acetylcholine (ACH), histamine (HIS), and CaCl2 caused the trachea to contract in a dose-dependent manner. Incubation of trachea with 10-7 M and 10-6M of CAPE induced a significant reduction in contraction induced by ACH and HIS. The degree of drug-induced tracheal contraction or relaxation was dose-dependent.

The CAPE potential to relax the trachea may antagonize cholinergic and histaminergic receptors of the trachea. The findings provide new insight into the effectiveness of CAPE in the control of asthma and the possible use of propolis for its treatment. The results highlight the anti-muscarinic, anti-histaminic, anti-inflammatory, and relaxant activities of CAPE and critically show its potential therapeutic effects.

Chronic eosinophilic pneumonia (CEP) is a rare idiopathic interstitial lung disease, predominantly observed in females. Eosinophilia is present in most cases, and alveolar eosinophilia is a diagnostic criterion in more than 40% of bronchoalveolar lavage (BAL) samples. The current study reported a 27-year-old male patient, non-smoker, with a history of uncontrolled asthma, presented to the emergency room with a complaint of cough, fever, and moderate dyspnea. A 30% eosinophilia was reported in his peripheral blood sample. A chest-X ray examination showed an upper and middle lobe consolidation, especially in the left lung. Broad-spectrum antibiotics were then started with a presumptive diagnosis of pneumonia, but no improvements were evident. The chest computed tomography scan showed air space opacities with septal thickening and predominant involvement of upper and middle lobes. Flexible bronchoscopy was performed, and the BAL sample analysis showed eosinophil infiltration, while negative culture. No parasites were identified. Transbronchial biopsies demonstrated eosinophil accumulation in alveoli and interstitium

Early recognition, diagnosis, and prompt treatment with corticosteroids are the main therapeutic approaches to CEP.

Tracheobronchopathia Osteochondroplastica (TBPO) is a rare disease with a benign period affecting the bronchial system. It is characterized by the presence of numerous osseous submucosal nodules or cartilaginous protruding into the tracheobronchial lumen. These wounds are diagnosed incidentally during bronchoscopy. We reported the stages of diagnosis and treatment of a 46-year-old patient with TBPO and concurrent chronic eosinophilic pneumonia.

A 46-year-old non-smoking Afghan male exposed to adhesives and chemicals in Iran for more than 25 years was admitted to a pulmonary ward with symptoms of exertional dyspnea, dry coughing, occasional nocturnal sweating for 6 years, tachycardia, hypoxia, and generalized wheezing during expiration. A symbicort inhaler and Montelukast pills were prescribed for him with the probable diagnosis of asthma. High-resolution computed tomography (HRCT) was performed on the patient and the results showed non-significant multiple lymph nodes with maximum diameters (SAD = 7 mm). HRCT also showed that the patient had protuberances on the trachea surface and thus underwent bronchoscopy for further examination. The results indicated numerous protuberances of white cartilage from the proximal part of the trachea to the distal part without the involvement of the posterior membrane. The biopsy result confirmed TBPO. Prednisolone was prescribed for the patient to treat the chronic eosinophilic pneumonia. However, we had to continue the daily dose of 5mg prednisolone due to the recurrence of the symptoms.

The lack of response to a bronchodilator in a patient suspicious to asthma must make us think about other causes of respiratory wheezing such as TBPO.