Journal of Inflammatory Diseases
Volume:24 Issue: 5, 2021

 One of the complications of diabetes, as a chronic metabolic disorder, is cardiovascular diseases. 
Objective This study aims to investigate the effect of an eight-week High-Intensity Interval Training (HIIT) program on serum Cardiac troponin I (CtnI) level in streptozotocin-induced diabetic rats. 

 In this experimental clinical trial, 30 rats were randomly assigned into three groups of healthy Control (C), Diabetic (D), and diabetic+training (D+T). The third group performed the training which included a treadmill running at an intensity of 85%-90% of maximum speed in 6-12 sessions of 2 min for 8 weeks, 5 days per week. Blood glucose level and high-sensitive CtnI levels were measured 48 hours after the last training session and 12 hours of fasting. One-way ANOVA and Tukey’s test were used to analyze the collected data, considering a significance level of P<0.05.

 The induction of diabetes caused a significant increase in blood glucose (P=0.01) and high-sensitive CtnI (P=0.01) levels in the D group. Also, a significant difference was observed in the blood glucose level of D+T group compared to the D group (P=0.001). The CtnI level also slightly reduced (11%) in the D+T group compared to the D group, but it was not statistically significant (P=0.591).

 he HIIT program can reduce the fasting blood glucose and increase the serum level of high-sensitive CtnI to some extent in diabetic rats; therefore, it can be an appropriate strategy for diabetics. However, there is a need for more studies in this area.

 Recurrent Pregnancy Loss (RPL) is a multifactorial disease that affects 1-3% of couples. Since Human Leukocyte Antigen-G (HLA-G) gene is involved in fetal maternal immune tolerance, mutations in the HLA-G gene can affect the success rate of pregnancy.

 The present study aims to investigate the haplotype effect of rs1736933 and rs2735022 polymorphisms found in the HLA-G gene on the RPL.Methods In this case-control study, participants were 100 women with RPL and 80 women with normal fertility in northwestern Iran. The HLA-G gene promoter was amplified by Polymerase Chain Reaction (PCR) method and sequenced. The genotype and allele frequencies of the two polymorphisms were compared between the two groups by using t-test in SPSS software version 22. Haplotype analysis was performed using PHASE 2.1 and Haploview 4.2 applications

 C allele and CC genotype in rs2735022 polymorphism and the G allele and GG genotype in rs1736933 polymorphism showed a significant association with the RPL (P<0.05). Frequency of haplotypes AA, AC, GA, GC were 0.72, 0.23, 0.01, 0.03 in patients and 0.39, 0.01, 0.02, 0.59 in the control group (P<0.05). The linkage disequilibrium score was 94.

 Analysis of GC haplotype in rs2735022 and rs1736933 polymorphisms of the HLA-G gene can be helpful in genetic studies of women with RPL.

 Due to the increasing life expectancy and aging population, attention to general health and marital satisfaction of older people can provide an opportunity to improve their living conditions.

 This study aims to assess the general health indicators of older couples to predict their marital satisfaction.

 This descriptive cross-sectional study was conducted on 110 older couples (men and women) living in Qazvin, Iran who were selected using two-stage cluster sampling technique. A demographic form, General Health Questionnaire (GHQ) and The ENRICH Marital Satisfaction Scale (EMSS) were used to collect data. Descriptive statistics and multivariate regression analysis were used for data analysis.

 The Mean±SD age of older women and men±SD was 64.15±5.46 years and 67.68±6.93 years, respectively. Their Mean±SD EMSS score was reported 109.72±12.58. Multivariate analysis showed that gender (β=0.169, P=0.050), age (β=0.097, P=0.567), age of marriage (β=0.214, P=0.002), somatic symptoms (β=0.233, P=0.013), anxiety/insomnia (β=0.227, P=0.008), social dysfunction (β=0.326, P<0.001), and depression (β=0.356, P<0.001) could significantly predict marital satisfaction.

 Different dimensions of general health can affect marital satisfaction of older couples. Therefore, interventions in these domains and the promotion of general health level can lead to increased marital satisfaction and, consequently, quality of life in the elderly.

 Psychological problems such as death depression can have adverse effects on Emergency Medical Technicians (EMTs) including reduced quality of medical services, job dissatisfaction, feelings of incompetence, depression, and reduced job values.

This study aims to determine the factors predicting death depression of EMTs in Iran.

 In this descriptive cross-sectional study conducted in 2019, participants were 125 eligible EMTs in hospitals affiliated to Qazvin University of Medical Sciences in Qazvin, Iran. Templer’s Death Depression Scale (DDS) and a demographic form were used to collect data. The collected data were analyzed using descriptive and inferential statistics.

 The mean±SD DDS score was reported 4.73±2.93. Most of subjects (n=79, 63.2%) had low death depression. According to the results of linear regression analysis, “number of resuscitation attempts in the last 3 months”, “organizational position” and “history of depression” were the predictors of death depression (P<0.05). In total, the regression model predicts 9% of the variance in death depression.

 Death depression of EMTs in Iran is low. Due to the importance of mental health in medical staff in providing quality clinical services, it is recommended that further studies should be conducted in this area using a larger sample size.

 Preeclampsia is a complex disorder of pregnancy with an unknown etiology. Numerous studies have shown the possible role of gene polymorphisms, especially metalloproteinases, in development of this disease, but there are no definitive results.

 This study aims to investigate the possible association between rs3918242 (−1562C>T) polymorphism in Matrix Metalloproteinase 9 (MMP9) gene with the risk of preeclampsia in pregnant women.

 In this cross-sectional study, participants were 90 pregnant women with preeclampsia and 199 healthy pregnant women (controls). The genotypes of rs3918242 polymorphism were investigated using Polymerase Chain Reaction technique and Limited Fragment Length Polymorphism method. Logistic regression analysis was used to investigate the relationship between rs3918242 polymorphism and preeclampsia. 

 The frequency of CC, CT, TT genotypes of rs3918242 polymorphism was reported 47.8%, 47.8% and 4.2% in patients and 84.8, 13.1 and 2% in controls, respectively, and the difference between groups was significant (P<0.001). The frequency of TT genotype in patients was significantly higher than in controls (P<0.001). Moreover, the frequency of T allele in patients was 52.2%, while in controls it was 15.2% and the difference between the two groups was significant (P<0.001).

 The rs3918242 polymorphism of MMP9 gene plays an important role in the incidence of preeclampsia in pregnant women.

 Despite the widespread obesity epidemic in the world, not all obese people are equally susceptible to the complications of obesity. Inflammatory factors play an important role in the complications of obesity.

 This study aims to evaluate the association of White Blood Cell (WBC) count with metabolic syndrome in overweight/obese men and women.

 This cross-sectional study is a part of the Qazvin Metabolic Disease Study (QMDS) conducted in 2010 in Qazvin, Iran. Participants were 622 obese people with a body mass index (BMI) ≥25 kg/m2, recruited from the QMDS. Metabolic syndrome was defined according to the Adult Treatment Panel III criteria. Data were analyzed using chi-square test, t-test, and logistic regression analysis (to evaluate the relationship between WBC count quartiles and metabolic syndrome).

 Prevalence of metabolic syndrome was not significantly different between men and women. In men, prevalence of metabolic syndrome and its components were not different between WBC quartiles. In women, 2.23% and 5.06% had metabolic syndrome in the first and fourth quartiles of WBC count, respectively (P<0.001). Moreover, the prevalence of insulin resistance was higher in fourth quartile compared to the first quartile (7.74% vs. 6.52%, P<0.001). After controlling the effects of age and BMI factors, the risk of metabolic syndrome in the fourth quartile of WBC count remained significant in women (OR=2.56, P<0.01).

 Association of WBC count with metabolic syndrome is significant in obese women compared to obese men.

 Optimal performance of health care tasks by the government in a way that promotes public health and development of the country is one of the most important pillars of governance.

 This study aims to present an optimization model for performing health care tasks by the Iranian government. In this model, the optimal interaction of governmental actors at the three action levels of governance (individual, organizational, and systemic) is examined.

 This is an applied descriptive study. Participants were 8 governmental management experts and 350 managers and deputies of the public, private, and non-governmental organizations in Iran. Data were collected by a researcher-made questionnaire. For designing the research model, fuzzy inference system was used.

 Promoting health care at the individual, organizational, and systemic levels was effective in optimally performance of the health care tasks by the government. At the individual level, civil society had a more important role, while the private and public sectors had a more important at the organizational and systemic levels, respectively. 

 For optimal performance of macro-tasks in the field of health care, the Iranian government needs to pay more attention to the interaction of civil society and the private, public, and military sectors.

The mortality rate of Coronavirus Decease 2019 (COVID-19) is very high, but specific situations can increase the rate including severe hypoxemia, multiple organ injury, and thromboembolic events in various organs. Another factor is the stress caused after surgery that require general anesthesia. This study aims to report a case of death in an adult woman with COVID-19 infection who had underwent septoplasty and admitted to hospital after worsening of her general condition and treated when diagnosed with COVID-19. One day after admission, she was intubated due to progressive respiratory failure and deceased following bradycardia and cardiac arrest. It seems that the elective surgery should be avoided in patients infected with COVID-19 and should be postponed until complete recovery. Moreover, the possibility of this infection should be considered in all candidates for surgery with subtle respiratory symptoms.

Mammalian mechanistic target of rapamycine (mTOR) is a conserved serine/threonine kinase in the cellular PI3K/Akt/mTOR signaling pathway. This pathway is modified by cellular alterations such as level of energy, growth factors, stresses, as well as the increased environmental level of cancerous cytokines. In general, increase of this kinase protein function is seen in various types of cancers, especially in cancer stem-like cell.  Additionally, activation of this pathway in the most common malignant central nervous system cancers such as glioblastoma, medulloblastomas and tuberous sclerosis complex is under investigation. Recent studies have shown the relationship between different cellular signaling pathways and genetic mutations, that involved in the cancer of CNS, with mTOR pathway. Based on previous studies, different treatments like surgery, chemotherapy, radiotherapy, aren’t more effective and have some side-effects. Therefore, the researchers are trying to find better ways to treat cancer. One approach to this aim is about the essence of understanding all of molecular pathways, proteins and mutations involved in cancers. This study tries to analysis some of the unknown molecular pathways on mentioned cancerous cells and interaction among this pathway with mTOR kinase protein.