مجله دانشکده پزشکی اصفهان
پیاپی 633 (هفته اول مهر 1400)

Salivary gland tumors are relatively uncommon. These tumors may occur in both major and minor salivary glands. The aim of this study was to evaluate the relative frequency of salivary gland tumors in patients referred to Alzahra hospital, Isfahan, Iran, during 2009-2019.

This study was a cross-sectional study. To collect the required information, salivary gland tumors registered in the pathology department of Alzahra hospital from April 2009 to April 2019 were examined, and the patient's demographic data including age, sex, and pathological information of the tumor including tumor type, location, lymph node involvement, vascular invasion, and perineural invasion were collected.

The total number of patients was 186 with age range of 14 to 79 years (mean 42.49 ±14.37), of which 94 (50.5%) were women and 92 (49.5%) were men. The frequency of benign and malignant tumors was 67% and 33%, respectively. The mean age of patients with benign and malignant tumors was 43.54 and 51.65 years, respectively. There were 110 patients (59.1%) with pleomorphic adenoma, 13 (7.0%) with warthin tumor, 40 (21.5%) with mucoepidermoid carcinoma, 8 (4.3%) with adenoid cystic carcinoma, 11 (5.9%) with acinic cell carcinoma, 3 (1.6%) with malignant mixed tumor, and 1 (0.5%) with myoepithelioma.

According to our findings, pleomorphic adenoma and then warthin tumor were the most common benign tumors, and mucoepidermoid carcinoma was the most common malignant tumor. The most common site of involvement was the parotid salivary gland.

Testicular torsion is associated with inflammatory response. Detorsion is one of the treatment methods in testicular torsion. The aim of this study was to investigate the effect of crocin administration before detorsion on sperm parameters and serum testosterone level.

Mice were randomly divided into five groups. Control group had only incision in the scrotum region; three treatment groups in which left testis was twisted for two hours, and then 25, 50, or 100 mg/kg crocin was injected intraperitoneally before detorsion; and in sham group, distilled water was injected before detorsion. After 24 hours, sperm parameters were evaluated using eosin-negrosin staining, serum testosterone level was evaluated using enzyme-linked immunosorbent assay (ELISA) kit, and histopathological changes were evaluated using hematoxylin-eosin staining via CellSens Entry software. Data were analyzed using analysis of variance, at the significance level of P < 0.05.

Administration of 100 mg/kg crocin improved sperm viability in treatment group. Although the mean testosterone level in the treatment groups was 1.2.01 ± 0.39 ng/µl, no significant difference was observed with the other groups. The mean epithelium height of the seminiferous tubules was 53.74 ± 1.53 μm in the control group, and 41.13±1.39 μm in the treatment groups, and in the sham group it decreased significantly (1.41 ± 31.12 μm).

Crocin may have improved some of the study indicators by compensating the inflammatory effects.

This study aimed to compare the cognitive functions (memory, executive function, language, and intelligence) and quality of life in patients with treatment-resistant frontal lobe epilepsy before and after frontal lobe surgery.

The present research was a longitudinal study in which patients were followed up one to three years after surgery. The statistical population included all patients with treatment-resistant frontal lobe epilepsy referred to Ayatollah Kashani Center in Isfahan, Iran, who underwent surgery. 24 patients were selected by convenience sampling method, and completed the Wechsler Memory Scale-Third Edition (WMS-III), the Tower Of London (TOL), the Persian Aphasia Naming Test (PNT), the Persian Diagnostic Aphasia Battery (AQ), the Wechsler Adult Intelligence Scale-Revised (WAIS-R), and the Quality of Life in Epilepsy Inventory (QOLIE-89) before and after surgery. The data were analyzed using paired t-test in SPSS software.

 The rate of seizures after surgery (1.02 ± 0.89) decreased compared to before it (4.29 ± 3.08) (P = 0.001). Compared to before surgery, patients significantly improved in working memory (P = 0.010), temporal performance in language (P = 0.050), executive functions (P = 0.010), intelligence quotient (IQ) function, especially operational intelligence (P = 0.001), and quality of life (P = 0.05) after surgery. Moreover, there was no significant difference between patients' performance before and after surgery in general executive, general memory, and verbal intelligence.

 Frontal lobe epilepsy surgery has a positive effect on some functions, and does not have any negative effect on some functions at least. Therefore, frontal lobe epilepsy surgery can be a good option for people with treatment-resistant frontal lobe epilepsy.