مجله دانشکده پزشکی اصفهان
پیاپی 660 (هفته چهارم فروردین 1401)

The way of coping with infertility affects the mental health of infertile couples. The association of coping strategies and adaptability in women who underwent assisted reproductive treatment are controversial. The aim of the present study was to determine the relationship between coping strategies and adaptability in infertile women who underwent assisted reproductive therapy.

This cross-sectional study was conducted on 212 women who underwent assisted reproduction treatment using convenience sampling. Adaptability to infertility and coping strategies were evaluated using validated self-report questionnaires. Statistical analysis was performed using the multivariable linear regression test. The structural equation modeling was done using AMOS software version 24.

The results showed that independent of the age, monthly income and duration of infertility, there was a negative significant relationship between adaptability to infertility and self-blame, ruminative self-focus, emotional expression, and emotional understanding. Although, a positive significant relationship between adaptability and liberation of the mind strategy exists. The overall structural equation model analysis represented good fit for the model indicating the relationship between coping strategies and infertility adaptability (CMIN/DF = 0.46, P = 0.91).

The results showed that in women who underwent assisted reproductive therapy, only the use of mind liberation strategies had a positive effect on adaptability and other coping strategies had an inverse effect with adaptability.

Exercise and antioxidants are well known for the protection against the risk of diabetes. Therefore, the purpose of the current study was to investigate the effects of intermittent exercise and thyme honey on the proliferation and differentiation of cardiac cells in male rats with type 2 diabetes.

This experimental study was performed on 36 male diabetic rats which were randomly divided into four groups: control (n = 8), HIIT (n = 10), thyme honey (n = 8) and HIIT*thyme honey (n = 10) groups. The HIIT intervention of 8 weeks, including 2 to 8 of intrmittent running for 2 mins at 80-90% VO2max and 1 min at 50-56% VO2max, was performed for 5 sessions per week. Additionally, 3 g/kg thyme honey was fed, 5 days/week, in supplement groups. Both Nkx2.5 and Tbx5 genes expression in heart tissue was measured by real-time RT-PCR. To evaluate the differences between the groups, ANOVA and LSD post hoc test were used with the significance level of P ≤ 0.05.

Analysis revealed that expression of Nkx2.5, Gata4 and Tbx5 gene were significantly higher in HIIT compared with the control group whereas these findings were not repeated in Tbx5 and Nkx2.5 indices of the honey group (P > 0.05).

The HIIT is associated with increased expression of Nkx2.5, Tbx5 and Gata4 (1)genes in heart tissue of diabetic rats, while thyme honey did not have similar benefits in diabetic rats.

Maintaining a normal blood glucose level depends on the proper and coordinated functioning of several systems in the body. Understanding the various molecular mechanisms that regulate blood glucose levels has significant implications for maintaining human health. Insulin resistance can alter the secretion of cytokines or peptides called myokines, which are secreted from skeletal muscle tissue after glucose uptake. Irisin is a recently identified myokine secreted by skeletal muscle. Irisin is a secreted form of fibronectin type 111 domain containing-protein5 (FNDC5) with 112 amino acids and 12 kDa molecular weight. Increasing circulating irisin improves insulin resistance, weight control, cardiovascular and brain health. The secretion of this myokine is regulated by skeletal muscle and to a lesser extent by adipose tissue by various factors. The aim of this review study was to investigate the different pathways of irisin signal transduction pathways that lead to the regulation of carbohydrate and lipid metabolism in different tissues of the body in insulin resistance and type 2 diabetes through in vivo and in vitro experiments. The findings of this review study indicate the important role of irisin in regulating metabolic pathways in the human body. Irisin could be considered as a new therapeutic target in the treatment of metabolic diseases such as insulin resistance and type 2 diabetes.