مجله دانشکده پزشکی اصفهان
پیاپی 682 (هفته دوم مهر 1401)

Breast cancer is the most common type of malignancy seen in women globally and the second life-threatening cancer among women after lung cancer. This research aims to compare the dosimetric differences based on two radiotherapy treatment plans for left breast cancer after surgery.

CT scan data from 20 patients who were candidates for radiotherapy diagnosed with left breast cancer were randomly selected and sent to the treatment design software. The target organ (left breast) and organs at risk including lungs, heart, right breast were contoured by the radio-oncologist. The design of three-dimensional conformal radiotherapy (3D-CRT) was designed using two opposite tangential beams, depending on the patient's anatomy, with and without wedge and with energy of 6 MV. The tomotherapy treatment was designed with an energy of 6 MV. Finally, using the dose-volume distribution curve (DVH), the dosimetric variables of the target organ and the organs at risk were extracted and compared with each other.

The three-dimensional conformal radiotherapy method reduced the average dose of the target organ and organs at risk compared to the tomotherapy method. The compliance index and homogeneity index were improved in the tomotherapy method, although the volume coverage of the left lung organ increased at low doses compared to the three-dimensional conformal radiotherapy method.

The tomotherapy method is a more suitable method for treatment than the three-dimensional conformal radiotherapy method as it enhances the target volume coverage and offers a better dose distribution.

High-intensity intermittent exercise (HIIE) is an increasingly popular exercise program that provides positive results with short sessions. The aim of this study was to evaluate the effect of one session of HIIE on muscle damage and inflammation.

Twenty-five male Wistar rats were randomly divided into three groups: control (Control, n = 8), HIIE, which were euthanized one hour after training (HIIE-1h, n = 8), and 24 hours after training (HIIE-24h, n = 9). HIIE group was subjected to a high-intensity interval exercise (VO2max 85-100%) that included ten exercise-recovery sets which was composed of 10 bouts of high intensity exercise of 1 min each (85-100% of VO2max), at 28 m/min, 10° inclinations on the treadmill interspersed by 2 min of active recovery, at 10 m/min, with no inclination. Serum IL-6 and IL-8 levels and the skeletal muscle inflammation and damage were assessed. Analysis of variance at 95% confidence level was used to analyze the data.

Serum IL-6 and IL-8 levels in the HIIE-1h and HIIE-24h groups showed a significant increase compared to the control group. Also, the pathology results showed that the inflammation and rhabdomyolysis of muscle fibers in the tibialis anterior muscle in the HIIE-24h and HIIE-1h groups were significant compared to the control group.

An HIIE session leads to inflammation and rhabdomyolysis in skeletal muscle. Serum IL-6 and IL-8 levels also showed a significant increase that could be associated with muscle damage and inflammation.

One of the Arboviral diseases mostly transmitted by mosquitoes of the family Culicidae is Sindbis virus (SINV). Conduction of studies on the distribution of the distribution of vector-borne viruses and their prevalence has become very important in recent years. The present study aimed to investigate the status of this virus in Iran and adjacent countries by reviewing published literature.

Various databases including Magiran, IranDoc, Civilica, Jihad Daneshgahi Scientific Information Center (SID), Web of Science, Scopus, Science Direct, Google Scholar, and PubMed were investigated in both Persian and English languages.

The results indicated the evidence of the presence of the virus in Iran and eight neighboring countries. Evolutionary analysis and alignment of registered sequences in GenBank showed 100% similarity of sequences registered from Iran with a number of sequences registered from Armenia and Russia.

The current review of the studies and sequences registered in GenBank shows the presence of the virus in Iran and other countries in the region. So far, very few studies have been carried out on the epidemiology of this virus in Iran and the Middle East. Further studies in different parts of these regions are recommended.