مجله دانشکده پزشکی اصفهان
پیاپی 704 (هفته چهارم اسفند 1401)

Respiratory sleep disorder is one of the most common sleep disorders. The aim of this study was to investigate the factors affecting sleep apnea in workers working in one of the aluminum industries.

This descriptive-analytical study was conducted in one of the aluminum industries in the south of Iran in 2021. The lung capacity of the workers was assessed according to the guidelines of the American Association of Lung Specialists. Berlin questionnaires were used to assess obstructive sleep apnea. Data were analyzed using T-test, Pearson correlation coefficient, and multiple logistic regression.

In this study, 152 workers in the aluminum industry with an average age of 33.63 ± 6.34 years and a body mass index of 25.06 ± 3.07 participated. 34.9% of workers were at high risk for obstructive sleep apnea. Age (OR = 1.23, 95% CI = 1.08-1.37), body mass index (OR = 1.57, 95% CI = 1.18-2.08), and FEV1 / FVC (OR = 0.76, 95% CI = 0.59-0.98) were significantly associated with an increased risk of sleep apnea (P < 0.001)

Workers, in the aluminum industry, have a higher risk of developing obstructive sleep apnea. Age, body mass index, and FEV1 / FVC are the main predictors of sleep apnea. These variables should be considered in the screening tests and clinical trials.

The main cause of death in diabetic patients is cardiomyopathy. Regular exercise improves insulin resistance and reduces the mortality of diabetic patients. The aim of this study was to compare the effect of six weeks of aerobic and resistance training on the expression of miR195 (specific to the myocardium) in male rats with diabetic cardiomyopathy.

Male rats with an average weight of 200 ± 20 grams and age of 8 weeks were randomly divided into four groups of 6 (sham, control, resistance and aerobic training) after the induction of diabetes (50 mg/kg STZ). A healthy group (n = 6) was also considered for comparison with the diabetic group. Exercise protocols were performed for 6 weeks. The expression level of miR195 was evaluated using PCR-Real Time. One Way Anova and T-correlated statistical tests were used for data analysis.

Both aerobic and resistance protocols led to a significant decrease in fasting blood glucose and insulin resistance index (HOMA-IR). Vvo2peak of the aerobic group and 1RM of the resistance group increased significantly. The expression of miR195 in the diagnostic and solar control groups was more different than the healthy group, but it was less in the exercise groups.

Compared to aerobic exercise, resistance training had a better effect on the expression of miR195 and diabetes indicators. Therefore, it is recommended that patients with cardiomyopathy should focus on resistance training.

Neurofibromatosis is one of the phacomatosis syndromes that affects different organs in the body and is divided into two types. Neurofibromatosis type 1 can cause eye involvement in various forms, including eyelid, conjunctiva, iris or optic nerve involvement. Involvement of retinal vessels in the form of retinal ischemia is rare in this disease and usually occurs in the second or third decades of life and is controlled by laser treatment or surgery.

Case Report:

 In this report, we introduce a 3-year-old girl with neurofibromatosis type 1 who suffered severe retinal ischemia. This child suffered unilateral retinal involvement in the form of ischemic retinopathy with retinal and vitreous hemorrhage in her left eye, and despite two vitrectomy and retinal laser surgery in the left eye, the retinal involvement progressed and eventually the vision in the left eye was lost.

This report shows for the first-time retinal involvement at a young age in a patient with neurofibromatosis type 1 and its resistant nature.