Journal of Current Oncology and Medical Sciences
Volume:3 Issue: 1, Winter 2023

Colorectal cancer (CRC) is the third common cancer among human and the fourth common reason of mortalities caused by cancers around the world. During recent years, EGFR-related molecular pathways are known as an important therapeutic pathway. High frequency of mutations of RAS family such as KRAS and NRAS and their rapid incidence in colon cancer indicates their high potential as a biomarker for early detection.

In this cross sectional retrograde study, patients with colorectal cancer referring to Golestan Razi and Poursina Hospitals in Iran were evaluated during years 2009-2018. The rates of KRAS and NRAS factors were evaluated on paraffinized pathology samples of patients with metastatic colon cancer. Then, the correlation between mutation in these two factors with other clinicopathological findings of patients such as age, gender, tumor grade, location of primary lesion, time to progression (TTP), family history and presence or absence of lymphovascular invasion was investigated.

There was no significant correlation observed between occurrence of NRAS and KRAS with age group, family history and gender in the present study. But there was a significant statistical correlation between the rate of NRAS gene incidence with location of primary lesion and tumor grade. Finally, there was found a significant correlation between both KRAS and NRAS genes with TTP, so that TTP of patients reported less than patients without mutations in both groups.

The present study showed that presence of both mutations in KRAS and NRAS makes the prognosis of disease worth such a way the location of primary lesion and tumor grade are two effective factors in incidence of NRAS gene and lymphovascular invasion is the effective factor on KRAS gene incidence. also, TTP is lower among patients with mutations in both KRAS and NRAS genes.

Pressure ulcer is a pressure-induced tissue injury that can affect the skin, muscle, connective tissue, cartilage, and bone. Pressure ulcer is a painful, debilitating condition that endangers a person's health by increasing mortality and morbidity in terms of length of hospital stay, increasing the rate of infection, and the need for surgical procedures. Pressure ulcers are the third most expensive disease after cancer and cardiovascular diseases. About two-thirds of hospital beds are occupied by people over 65 years old. This study aimed to determine the prevalence of pressure ulcer and its related factors in elderly patients hospitalized at teaching hospitals in Guilan, Iran.

This was a descriptive cross-sectional study in which elderly patients who had been hospitalized for 24 hours or more in the intensive care units, internal and surgical wards of East Guilan educational hospitals were eligible for the study. Using the available stratified sampling method, 250 patients aged 60 years and older were included in our study. Data collection tools included socio-demographic and medical profile questionnaires and the Braden pressure ulcer risk assessment scale. Data were analyzed using SPSS version 22 statistical software. Descriptive statistics, Pearson correlation, Chi-square, and Fisher's exact tests were used to analyze data at a significant level of P<0.05.

The prevalence of pressure ulcer in elderly patients hospitalized in teaching hospitals in was 26.4%. There was a significant relationship between the presence of pressure ulcer with age, length of hospital stay, type of ward, urinary and fecal incontinence, edema, level of consciousness, type of mattress used, connection to mechanical ventilation, position change, sensory perception areas, humidity, activity, and mobility. There was no significant relationship between the presence of pressure ulcer with gender, marital status, and surgical history.

Pressure ulcer has a high prevalence in hospitalized elderly and it is always accompanied by serious complications. it is better for nurses to check patients regularly and prevent its occurrence by controlling significant risk factors.

Longitudinal melanonychia (LM) is a common clinical condition that is mostly identified by the presence of longitudinal, demarcated, and pigmented bands on the nail. Different benign or malignant pathologies can present with longitudinal melanonychia. Therefore, we aimed to investigate the frequency of dermoscopic features of LM in patients with LM referred to dermatology clinics in Guilan, Iran.

This case-series study was conducted on 30 patients with LM who were referred to Besat clinic and Razi hospital, Rasht, Iran, from March 2022 to August 2022 with a complaint of LM. Demographical data and dermoscopic findings of patients were collected and analyzed using SPSS version 21. The LM and dermoscopic features were investigated using a dermatoscope (HEINE IC1, HEINE Optotechnik, Germany).

Out of 30 patients, 24 patients were female and 6 patients were male with a mean age of 30.08 ± 14.31 years old. Among these patients, five patients had a family history of LM, one patient with melanoma had Hutchinson’s sign, and three patients had pseudo-Hutchinson’s sign. The mean width of lesions of the nail was 2.42±2.12 mm with a mean time of onset of 7.42 ± 7.12 months. Also, the majority of the involved site of LM was hand (26.6%).

According to our study, LM was more frequent in females and the trauma-related lesions of the nail were the most common dermatological findings among the patients.

The emergency ward is one of the most important parts of the hospital, where people's activities can have many effects on the performance of other wards of the hospital and the satisfaction of patients. Changing lifestyle and transformation of cyberspace into one of the pillars of modern life has had a great impact on learning and teaching methods. To compare the level of theoretical emergency learning in medical students with two virtual and traditional methods.

This quasi-experimental study was conducted on 88 medical students who started their emergency rotation in two hospitals of Guilan University of Medical sciences in 2021. Both groups participated in the same exam before and after the basics of electrocardiogram (ECG), normal ECG, types of blocks, diagnosis of MI and arrhythmias education. After collecting the information from the questionnaires, the data analysis was performed via SPSS software with a significant P<0.05.

Out of 88 students, 56.8% were female, and 43.2% were male. The mean and median knowledge score before and after education was statistically significant in two groups (P<0.001). The virtual group represented a higher average score of knowledge than the traditional group. The student’ grade point average affected the result of the score after education (P=0.019, β =0.234).

The use of virtual education methods in combination with traditional methods might help to improve the learning process and knowledge of medical students in emergency department.

Strongyloides stercoralis a globally widespread human intestinal nematode. Hyperinfection mainly appears in patients with defective immune systems . This study intended to investigate the prevalence of serum positive Strongyloides stercoralis in cancer patients who have never undergone chemotherapy and those who received at least one cycle of chemotherapy.

This study targeted cancer patients, referred to Rasht hospital, and assigned them to two groups of cancer patients with no history of chemotherapy and cancer patients with at least one cycle of chemotherapy. Patient’s demographic information, underlying diseases and chemotherapy regimen were recorded, and their serum sample was examined.

410 patients were included in this study. the majority were female ( 51/7% ). About 40 patients tested positive for serology, out of which 14 were in the chemotherapy-treated group and 26 in chemotherapy-untreated group, indicating that the prevalence of serum positive Strongyloides stercoralis was significantly higher in patients with no history of chemotherapy. Moreover, eosinophilia significantly correlated with the prevalence of seropositivity. The chemotherapy protocol containing high doses of corticosteroids could multiply the risk of positive serology by 12.7 times.

Before chemotherapy, in areas with a higher prevalence of Strongyloides stercoralis, especially in high corticosteroids protocols, it may make sense to study Strongyloides stercoralis . It becomes more vital in men and eosinophilic patients. Since serologic testing may display false negative rates in patients with defective immune systems, subsequently, alternative complementary methods such as fecal larval examination and fecal PCR test are highly suggested to be carried out along with serology.

SARS-CoV2 is the third strain from Corona family with zoonotic roots which has spread among humans from the beginning of this century. We conducted this study to examine mortality and its related factors among all patients admitted to Razi Hospital with suspicion of COVID-19 between February and April 2020.

In this analytical cross-sectional study,after obtaining permission from the ethics committee under the university’s research deputy, the required information such as demographic data, clinical symptoms and imaging study results was collected by reviewing records of all patients with COVID-19 suspicion.

From 1792 cases, 1045 patients were male and 747 patients were female. Mortality was 27% in all patients and 30% and 22% in men and women. The highest hospitalization rate was in the age group of 51-60 years and the highest mortality rate was in the age group of 81-90 years. 1472 patients lived in urban areas and 316 patients in rural areas. 997 patients had 93% O2 Saturation and less, of which 36% died. PCR test was performed for 505 patients, of which 69% were positive. Chest CT scan was performed in 96% of patients and chest X-ray was performed in 66% of patients with COVID-19.The most common symptoms were shortness of breath, cough, fever, chills, weakness, nausea and headache, respectively. The highest mortality was in patients with impaired consciousness at the beginning of hospitalization.

The results of the present study showed that male gender, older age, history of underlying disease, Chest x-ray involvement, drug use, shortness of breath and lesser O2 Saturation are associated with adverse outcomes, constitutional and gastrointestinal symptoms are associated with better outcomes in patients with COVID-19.

Kyphosis is the spinal curve that causes the top of the back to seem abnormally rounded. Carrying angle can be measured with the upper limb being fully extended. The study aim was determining the mean and correlation between kyphosis and carrying angle with demographic factors in medical students of Guilan University of Medical Sciences.

In this observational study, we assessed asymptomatic young adults in their first three years of enrollment in medical school. The participants had neither current nor a history of spinal or upper arm injuries. Kyphosis and carrying angle were measured by using the Debrunner kyphometer and goniometer, respectively. We also measured anthropometric features such as weight and height.

We studied 217 medical students (M/F= 1.17/1), with a mean age of 21.43±2.06. Kyphosis has a statistically significant negative correlation with height, weight, and carrying angle of both dominant and non-dominant upper limbs. We found kyphosis to be greater in female than in male participants. Carrying angle was greater in the dominant upper limb than the non-dominant upper limb. Dominant upper limb carrying angle was also positively correlated with height and weight.

In asymptomatic young adults with no history of spinal diseases, anthropometric features such as height and weight impact kyphosis angle. It seems that kyphosis is greater in females. Severe changes in kyphosis angle may cause loss of sagittal orientation. We suggest that people at risk of kyphosis be screened in early adulthood to prevent the increase of kyphosis and its subsequent complications.

Hakim Mohammad, a military physician, and surgeon of the Safavid Era (1501 to 1736) and the author of Dhakhira-Yi-Kamilah book, served as a young man in the Ottoman Empire Officer as a surgeon physician. In this study, the method of suturing by Hakim Mohammad has been introduced. Suturing with ant was a wound healing method that was carried out by Hakim Muhammad to treat the wounds of certain areas of the body, by a special species of ants called fire ants, and by the lower jaw of these ants. Also, Hakim Mohammed suggested specific food and drug in order to take care of the wound and control infection and pain followed by this type of suture. Study of the treatment methods of predecessors shows us developments and the path to the progress of surgical affairs and can be used in the direction of further advances.

 The unexpected spread of COVID-19 with high risk of transmission, fear and anxiety, and a load of negative emotions followed for nurses. It is necessary to assess the psychological experiences of nurses during the first peak COVID-19 pandemic.

 In this qualitative study, with the approach of conventional content analysis approach, the participants were selected through proposed-based sampling and snowball from the COVID-19 centers of Guilan province in March 2020. The number of 20 participants with various demographic characteristics (Gender, age ...) entered the study. The tools used were in-depth and semi-structured interviews.

 Most of the participants were women, married and nurses.  Six categories were obtained: not perception, worries, and pretending, horrible observations, pre-psychological symptoms and psychological symptoms.

 Psychological experiences of nurses in  COVID-19 center in Guilan were expressed in a range of not perceptions and worry until the appearance of numerous pre and psychological symptoms. The psychological needs of this group must be considered at all stages of the crisis. Psychological support by mental health workers should be considered in line with the development of the crisis to reduce the stress on nurses.