Iranian Journal of Diabetes and Obesity
Volume:15 Issue: 1, Spring 2023

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Diabetes mellitus (DM) is a leading cause of morbidity and death worldwide. DM will affect 570.9 million people worldwide by 2025. The usefulness of vitamin C in improving diabetes control has been a point of contention.

This clinical-trial double-blind study with control groups was conducted on 164 patients with type 2 diabetes mellitus (T2DM). The intervention group received 1000 mg of oral vitamin C daily, and a placebo was administered to the controls. To analyze the obtained data, one-way ANOVA was used in SPSS software (version 20). A P< 0.05 was considered statistically significant.

Fasting blood sugar (FBS), hemoglobin A1c (HbA1C), triglyceride (TG), and high-density lipoprotein (HDL) were improved significantly in the intervention group (P< 0.05), while the low-density lipoprotein (LDL) and cholesterol were unaffected (P> 0.05). HbA1C and LDL levels in the control group increased significantly (P< 0.05). Meanwhile, this group's HDL levels decreased considerably.

Our findings support the consumption of vitamin C to complement the primary treatment for DM. According to our results, vitamin C provides a clear benefit over a placebo in the treatment of diabetic patients' serum parameters.

This study aimed to investigate the effectiveness of cognitive behavioral stress management (CBSM) on health-related quality of life (HRQOL), self-efficacy of diabetes management, and adherence to treatment of patients with type 2 diabetes.

The present study was a semi-experimental study with a control group. The research samples included 30 patients with type 2 diabetes. Data collection tools in this study included the Boyer & Earp quality of life (QOL) scale for patients with diabetes (D-39), the diabetes management self-efficacy scale (DMSES), and treatment adherence questionnaire in patients with chronic diseases. The CBSM therapy was performed in 8 sessions for the experimental group. To analyze the data, a univariate analysis of covariance was used with SPSS-23 software.

The results showed that the CBSM had a significant effect on the overall health-based QOL (F=8.620; P=0.007), diabetes management self-ffficacy (F=12.021; P=0.002), and treatment adherence (F=83.253; P=0.0001). In addition, the CBSM has a significant effect on diabetes control (F=8.932; P=0.007), anxiety and worry (F=5.023; P=0.035), and sexual functioning (F=7.611; P=0.011), diet (F=10.041; P=0.004), therapeutic regimen (F=24.250; P=0.0001), making effort for treatment (F=22.987; P=0.0001), intention to take the treatment (F=108.001; P=0.0001), adaptability (F=28.704; P=0.0001), and integrating illness into life (F=38.263; P=0.0001).

The CBSM intervention can be used to improve health-based QOL, diabetes management self-efficacy, and treatment adherence in type 2 diabetes patients.

Recently, the association between sexual dysfunction (SD) and diabetes has been proven in various studies. The study aimed to determine the frequency of SD and identify risk factors related to SD in men with Type 2 diabetes mellitus (T2DM).

The cross-sectional study was conducted on 114 men with T2DM who had referred to the Yazd Diabetes Center from 2019-2020. All of them filled out a standard questionnaire with a specified validity and reliability. The analysis was performed using ANOVA and Chi-square by SPSS, version 22 software.  

The mean age of participants was 52.48 (±5.33). The SD frequency was 73.7%. The mean SD score was 17.89 (±12). There was a significant relationship between the total SD and neuropathy (P: 0.0001), retinopathy (P: 0.0001), nephropathy (P: 0.023), type of treatment (P: 0.0001), age (P: 0.0001) and addiction (P: 0.031). There was no significant relationship between the total SD score and hyperlipidemia (P: 0.371), hypertension (P: 0.683), Hb1Ac (P: 0.816), duration of diabetes (P: 0.101) and smoking (P: 0.29).

Due to the high frequency of sexual dysfunction in men with T2DM, it is recommended that SD be considered as an important complication in these patients so that by identifying indicators related to this complication in patients with diabetes, sexual health clinics take the necessary measures to solve sexual problems in these patients.

The purpose of this study was to compare eight weeks of exposure to sunlight and Home-Based Pilates Training serum vitamin D, CCL20, and the body composition of women with multiple sclerosis.

This study was a quasi-experimental study. Among women with Multiple sclerosis (with2-5EDSS), 44 were purposefully and voluntarily selected and randomly divided into three groups: Pilates at home) n=15), Pilates exposed to the sun (n=15) and control (n=14) were divided. The training program consisted of three sessions per week for eight weeks, consisting of two parts, Pilates training at home and Pilates training in the environment. An exercise program on the DVD was provided. The Serum vitamin D, CCL20 indices, and body composition of patients with MS were measured 48 hours before and after eight Pilates exercises at home and under sunlight. To analyze the data, analysis of covariance and Bonferroni post hoc test, SPSS software, and P≤ 0.05 significance level.

Comparing the results in the two stages showed that there was a significant difference between CCL20 (P= 0.001), serum vitamin D (P= 0.001), BMI (P= 0.001), weight (P= 0.001) and WHR (P= 0.001) indices of women with MS in the studied groups. These differences were only between the training groups and the control group. However, there was a significant difference in the CCL20 index and serum vitamin D between the two training groups (Respectively P= 0.037, P= 0.001).

Patients with MS can improve their vitamin D level and weight-related and inflammatory indicators by using Pilates exercises exposed to sunlight and at home with minimal cost.

Obesity is one of the most frequent concerns among teenagers, and it may lead to a variety of chronic disorders including heart disease and cancer. The present study aimed to assess the effectiveness of cognitive-behavioral therapy (CBT) on body shay and self-criticism of obese adolescents referred to nutrition clinics in Tehran in 2019.

This study used a quasi-experimental method and a pre-test-post-test with a control group. Twenty-four obese volunteer adolescents were selected and assigned to an experimental group (n=12) and a control group (n=12). The experimental group received 90-minute weekly sessions for 2.5 months (10 sessions), while the control group did not receive any intervention. Before and after the training phase, all the participants completed the body image shame scale (BISS ) and the Forms of Self-Criticizing/Attacking and Self-Reassuring Scale (FSCRS). Data were analyzed through multivariate analysis of variance (ANCOVA) by using SPSS 22 software.

The CBT group decreased significantly more in body shaming and self-criticism of obese adolescents compared with the control group (P< 0.001).

In general, the findings revealed a substantial difference in body shaming and self-criticism among obese teenagers between the experimental groups. In obese teens, CBT reduced body shaming and self-criticism. Furthermore, this research showed that CBT could help obese teenagers with body shaming and self-criticism.

The role of post-exercise on the neutrophil-lymphocyte ratio (NLR) and platelet-lymphocyte ratio (PLR) is not evident in pediatrics with type 1 diabetes (T1D) yet. This paper reports the results of a research study on how concurrent exercise training affects NLR and PLR in children with T1D.

In this randomized controlled trial, 40 children (boys and girls aged 11.11 ±2.29 years) were randomly divided into an experimental (n=20) and a control group (n=20). The training program included concurrent resistance-aerobic training, which was intermittently performed for 60 minutes at a rate of three times a week for 16 weeks. The participants were analyzed for blood glucose homeostasis, NLR and PLR before and after the program. Data were analyzed by SPSS 22 software with paired T-test and covariance analysis (P< 0.05).

The results showed that PLR significantly (P= 0.002) decreased in the exercise group after 16 weeks of concurrent training. This significance was observed between the groups too (P= 0.003). HbA1c decreased both in the exercise group and between the groups (P= 0.001, P= 0.003). NLR exhibited a significant increase both in the exercise group (P= 0.021( and between the groups )P= 0.012(.

Concurrent exercise training reduces PLR and HbA1c in children with T1D, which may be related to the anti-inflammatory effects of exercise training.

Diabetes is characterized by a comprehensive increase in apoptosis, mitochondrial dysfunction, and inflammation in skeletal muscle. Impaired mitochondrial function in skeletal muscle leads to an increase in Cytochrome C and Caspase-9, and muscle performance is reduced consequently. Exercise training through decreasing inflammatory factors and increasing anti-inflammatory elements prevents apoptosis pathways.

Forty male Wistar rats (150±10 g, 8 weeks age) were assigned to 4 groups: control (C), diabetes (D), high-intensity interval training (HIIT), and diabetes high-intensity interval training (DHIIT). Diabetes was induced with intraperitoneal injections of Streptozotocin (STZ) and blood sugar higher than 250 was considered diabetic. The effects of six weeks of HIIT on soleus muscles, Cytochrome C, and Caspase-9 gene expression, as well as evaluation of tumor necrosis factor-alpha (TNF-α) in serum were evaluated using Real-Time PCR  and ELISA techniques respectively.

In comparison with C group Diabetes has significantly increased the Cytochrome C (P= 0.001) and caspase-9 (P= 0.003). However, HIIT training in diabetic rats significantly decreased the Cytochrome C (P= 0.001) and caspase-9 (P= 0.008) in comparison of D group. Also, TNFα (P= 0.01) increased in the D group in comparison with C and DHIIT group (P= 0.001). In comparison between DHIIT groups in HIIT groups, has a significant increase in time to exhaustion post test than pretest (P= 0.001).

It seems that HIIT training decreases intrinsic factors of the apoptosis pathway by decreasing inflammatory factors which leads to significant improvement in skeletal muscle function and overall health in diabetic rats.