Jorjani Biomedicine Journal
Volume:10 Issue: 4, Winter 2022

Epidemiological studies have shown that high dose of ethanol can lead to apoptosis. On the other hand, the consumption of medicinal plants such as turmeric in the diet and performing physical activities are considered as factors to control apoptosis. Therefore, this article aims to mainly evaluate the anti-apoptotic effects of swimming and curcumin interactively during withdrawal of binge ethanol exposure in heart tissues.

In this study, 40 rats were received ethanol (25% W/V) as gavage for four days every eight hours. Then, 7 days after ethanol withdrawal, they were classified in 5 groups, including: (1) control, (2) curcumin, (3) swimming, (4) swimming with curcumin, and (5) sham. Groups 3 and 4 performed swimming five sessions a week for two weeks, and groups 2 and 4 received 50 mg/kg of curcumin five times a week for two weeks. The amount of BAX, BCL2, and P53 protein and BCL2/BAX ratio were measured using western blot technique. The data were tested using the independent t-test at a significant level (p≥0.05) and two-way ANOVA.

Swimming had a significant effect on reduction of p53 (F=60.051, P<0.0001, η2=0.741), Bax (F=62.594, P<0.0001, η2=0.887) and Bax/Bcl-2 ratio (F=290.591, P<0.0001, η2=0.973), and increase of Bcl-2 (F=150.940, P<0.0001, η2=0.950); Curcumin had a significant effect on decrease of p53 (F=5.513, P=0.029, η2=0.208), Bax (F=66.146, P<0.0001, η2=0.892) and Bax/Bcl-2 ratio (F=260.655, P<0.0001, η2=0.970), and increase of Bcl-2 (F=73.274, P<0.0001, η2=0.902). The results from two-way ANOVA showed the interactive effect of exercise and curcumin on the decrease of BAX (F=35.847, P<0.0001, η2=0.818) and BAX/BCL-2 ratio (F=175.887, P<0.0001, η2=0.956), and the increase of BCL-2 (F=21.205, P=0.002, η2=0.726) were significant; but it had no significant effect on p53 (F=0.000, P=0.999, η2=0.000).

Swimming and curcumin consumption simultaneously can significantly moderate apoptosis caused by ethanol in the heart tissue.

Oral cancer relates to oral and intestinal microbiota composition. Lactobacillus species are considered probiotic bacteria due to their ability to modulate human immune responses and therapeutic effects. This study aimed to investigate the effects of Lactobacillus plantarum (L. plantarum) on TLR4 gene expression and its downstream pathways in a mouse model of oral cancer.

This experimental study was conducted in the Stem Cell Research Center, Faculty of Modern Technologies, Golestan University of Medical Sciences, Gorgan, Iran, in 2021. L. plantarum strain ATCC 8014 was used in this study. Twenty-eight male Wistar rats were divided into four groups (n = 7). 4-Nitroquinoline 1-oxide (4NQO) was used to establish oral cancer in rats. A pathological examination was adopted to confirm cancer establishment. Rats were treated with probiotic L. plantarum before and after cancer development. After extracting RNA from blood and synthesizing cDNA, the ability of lactobacilli to modulate the expression of TLR4 genes was investigated by Real-Time PCR Methods (RT-PCR).

In the present study, it was observed that after causing cancer and treating the animal with L. plantarum, the expression of the TLR4 gene decreased significantly (P-value < 0.05), which might, in turn, affect the downstream pathways, which included the decrease in the expression of BCL-2 and NF-ĸB genes. Accordingly, the expression of the NF-ĸB gene was significantly reduced in rats received L. plantarumgavaged for two weeks after cancer induction.

According to the obtained results, probiotic L. plantarum significantly affects the gene expression of NF-ĸB and TLR4 in cancerous rats. It was also shown that L. plantarum was more efficient in reducing TLR-4 and NF-ĸB genes expression when it was gavaged for 14 days after tumor induction.

One of the complicated processes in the Ministry of Health is the process of registering pharmaceuticals .Since there are different soft wares for registration of products, and since parallel services concuss waste of time and money, it is necessary to provide integrated software in the form of services. This goal can be achieved when services are identified and combined in integrated soft wares.

present study is an applied research, In order to identify the services of an integrated system for recording pharmaceutical supplies, first the Gray-Wolf multi-objective optimization (GWO) algorithm was proposed. Then the values of the algorithm parameters were extracted by the goal-based requirements analysis method and the algorithm was implemented. Finally the best services were extracted by the hierarchical analysis process.

Considering that the results of present study are an operational project in the Ministry of Health, by implementing the algorithm proposed by Gray Wolf, services were identified, which can be used to create integrated software for registering pharmaceutical supplies.

Creating an integrated system for registering pharmaceutical supplies is one of the important challenges of the Ministry of Health. This can be achieved by identifying services and combining these services to create an integrated system.

As a health emergency of the 21st century, Diabetes is associated with an increased risk of cardiovascular diseases, stroke, diabetic nephropathy, neuropathy, retinopathy, pregnancy complications, psychological problems, lower quality of life experience, as well as a high economic burden and high risk of premature death. This study aimed to develop psychological interventions headings for patients referring to healthcare service centers based on local needs assessment through content analysis method of experts' opinion to provide services in the primary healthcare system.

This study was conducted on 19 mental health specialists, professors, and the health team providing services in healthcare service centers (family doctor and mental health expert) in 2018-19. The data obtained from the semi-structured interviews were analyzed using the directed content analysis technique.

The essential finding themes related to the closed headings of psychological interventions in diabetes for improving disease management included "collaborative care," "psychological assessment," the importance of "diabetes coexistence with psychiatric disorders," "creating health behaviors," "self-management training," and "intervention" In crisis" for the management of type 2 diabetes.

This qualitative study was conducted with the participation of mental health experts. Therefore, the mentioned themes and categories can be used in developing the headings of psychological intervention programs for type 2 diabetic patients, focusing on the needs of Iranian patients and the structure of the health system.

Despite significant advances in treatment, breast cancer remains a medical problem and the most common cancer leading to death among women worldwide. The most common breast cancer treatments, radiotherapy and chemotherapy are usually expensive and can cause severe side effects and low response rates due to drug resistance. To overcome these problems, medicinal plants can be the best alternative to chemotherapy drugs with fewer side effects and cost-effectiveness. Sesquiterpene lactones are compounds of the Asteraceae plant family that has significantly impacted various aspects of breast cancer cells. This review focused on the biological properties of Sesquiterpene lactones and their potential processes in breast cancer, leading to enhanced anticancer effects.

Obesity has been recognized as a global problem that is increasing day by day. Although t

Obesity has been recognized as a global problem that is increasing day by day. Although the favorable effects of training and herbal supplements have been reported in this regard, the synergistic effects of the two are still a challenge for researchers. The purpose of this study was to investigate the effect of six weeks of Aerobic Training (AT) and Curcumin (Cu) consumption on adiponectin gene expression in the visceral adipose tissue and some anthropometric indicators of rats fed with High-Fat Diet (HFD).

In this experimental study, 40 rats with HFD (1.5 mg/kg/day high-fat emulsion) were randomly divided into five groups, including: (1) Healthy Control (HC), (2) High-Fat Diet Control (HFD), (3) HFD+Cu, (4) HFD+AT, and (5) HFD+Cu+AT. Aerobic training was carried out for six weeks, five sessions per week and each session of training was performed 10-50 minutes at a speed of 25-30 meters per minute and a slope of 15 degrees. Also, curcumin was fed to rats by gavage in the amount of 1.5 mg/kg/day. One-way analysis of variance with Tukey's post hoc test was used to analyze adiponectin and ANCOVA test with Bonferroni's test was used to analyze BMI. Data were analyzed in Prism GraphPad PRISM 3.8.3 software (P≤0.05).

Adiponectin gene expression levels in the HFD+AT, HFD+Cu and HFD+AT+Cu groups were significantly higher than the HFD group (P≥0.05). Weight and BMI levels in the HFD+AT and HFD+AT+Cu groups were significantly lower than the HFD (P≥0.05). Also, in the HFD+AT+Cu group, the weight and BMI levels were significantly lower and the adiponectin levels were significantly higher than the HFD+Cu group (P≥0.05).

It seems that exercise training and curcumin consumption both individually and synergistically can be effective in improving anthropometric characteristics by affecting adiponectin levels.he favorable effects of training and herbal supplements have been reported in this regard, the synergistic effects of the two are still a challenge for researchers.

Little attention to sustainability in business, particularly in the healthcare sector, together with the absence of a model within acceptable limits for this purpose, were among the main objectives to design a business sustainability model for healthcare facilities (viz., hospitals and medical centers) in the present study.

The qualitative meta-synthesis approach was implemented in this study, and the most significant factors shaping sustainability in business were identified. The statistical population included the articles, books, and research reports published and retrieved from the reliable journals and databases, between 2002 and 2021. Moreover, the experts, i.e., the university professors and specialists involved in healthcare at Ilam University of Medical Sciences, Ilam, Iran, were consulted. At this stage, snowball sampling was done based on the model proposed by Sandelowski and Barroso, until theoretical saturation was reached. In total, 26 articles were selected and finalized for the meta-synthesis. The Critical Appraisal Skills Programme (CASP) was correspondingly utilized to assess the quality of the study samples, and Cohen's kappa coefficient (κ) was employed to measure the validity of the extracted codes.

The study findings demonstrated that the business sustainability model for the healthcare sector comprised of 3 categories (viz. environmental, social, and economic), 12 concepts, and 65 codes, with a very goodness of fit.

In sum, business sustainability in healthcare facilities could be achieved if all environmental, social, and economic components developed in the give model as well as the effective indicators within each category were taken into account.

Date Palm Pollen (DDP), which is found in the male date tree, actually fertilizes the female date tree, which is necessary for the growth of date fruit. It is consisting of sugarcane, protein, calcium, vitamins (B, C and E) and minerals. It has long been used in traditional medicine as a medicinal plant with fertility effects and increased libido. The information obtained from the studies shows that this pollen, due to its antioxidant and gonadotropin-stimulating compounds, can increase fertility and sexual potency in both women and men with two main mechanisms. The first mechanism is this effect on the stimulation of gonadotrophic hormones and the second is a reduction of oxidative stress in the testicular tissue and consequently a protective effect on the testicular tissue. Due to the presence of antioxidant compounds, the consumption of this pollen also applies its health-enhancing effects to other tissues such as the liver, intestines, and heart. As same as DDP, regular Physical Activity (PA) stimulates gonadotrophic hormones and also beneficially affects antioxidant status and redox balance. In recent years, researchers have paid attention to this pollen as an important factor to strengthen the health-enhancing effects of PA, and researchers have investigated the simultaneous effect of this pollen and PA. Despite the few studies done, it seems that this pollen can enhance the antioxidant and anti-inflammatory effects of regular PAs. Nevertheless, it seems necessary to further studies in this area.