نشریه سوخت و ساز و فعالیت ورزشی
سال یازدهم شماره 2 (پاییز و زمستان 1400)

Type 2 diabetes and obesity are associated with changes in the body's metabolism, which is a determining factor in the development of insulin resistance. The aim of this study was to investigate the effect of six weeks high-intensity interval training on Vascular endothelial growth factor A (VEGF-A) and Adipocyte fatty acid-binding protein (A-FABP) levels of adipose tissue in type 2 diabetic obese rats.

To implementation of this experimental research, 32 obese male wistar rats (weight 320±20 gr) randomly were divided into 4 groups including obese control, shem (obese), obese diabetic, obese diabetic - high-intensity interval training. Intraperitoneal injection of nicotinamide amide-streptozotocin was used to induction type 2 diabetes. high-intensity interval training program was performed 4 days a week for six weeks. VEGF-A and A-FABP levels in rat adipose tissue were measured using by ELISA kit.

the VEGF-A level in adipose tissue in the obese diabetic group was significantly lower than the obese control group (P=0.001). Also, A-FABP (P=0.001) and insulin resistance (P=0.004) was significantly higher in the obese diabetic group than the obese control groups. High-intensity interval training was associated with significant increase of VEGF-A and decrease A-FABP levels in adipose tissue and insulin resistance in obese diabetic rats (P=0.001).

It seems that high-intensity interval training can help improve adipose tissue metabolic parameters and insulin resistance in obese diabetic rats.

Exercise is recommended for the management of type 2 diabetes, but its effects on renal function in patients with type 2 diabetes are not well known. The aim of present study was to examine the effect of 8 weeks resistance training on glomerular filtration rate (eGFR) and CD5 antigen-like (CD5L) of male patients with type 2 diabetes. Twenty-two men (age: 51.5 ± 3.3 years and body mass index: 27.1 ± 3.2 kg/m2 mean ± SD) with type 2 diabetes participated as the subject. The subjects were randomly assigned to control or training group based on their eGFR. The subjects in the training group performed 3 sets with 8 to 15 repetitions of resistance training with 50-80% 1RM, 3 days a week for 8 weeks. The subjects in the control group were instructed to maintain their normal physical activity throughout the study. Fasting blood sugar, fasting insulin, insulin resistance, eGFR and CD5L were measured at baseline and 48h after the intervention. The results indicated that fasting blood sugar, insulin resistance index and CD5L decrease in the training group compare to the control group (P<0.05); however, fasting insulin has no significant change after the intervention. Although eGFR has no significant change in the training group; but it was decreased significantly in the control group (P<0.05). In summary, it seems that resistance training utilized in this study improves blood glycemic and renal function in patients with type 2 diabetes.

Interleukin-6 is the major cytokine involved in initiating the acute phase response, which triggers the synthesis of certain proteins in the liver, such as C-reactive protein. The aim of this study was to investigate the effect of different periods of active recovery on serum IL-6 and hs-CRP response after one session of intense intermittent activity in female swimmers.

In this quasi-experimental study, 10 female swimmers ranging in age from 20 to 26 years were divided into two experimental groups: group 1 (n = 10) and group 2 (n = 10). The subjects swam the distances of 25 meters with maximum speed, the active recovery time in experimental group 1 was three times the duration of swimming and in experimental group 2 was four times the duration of swimming. The intensity of activity during active recovery was considered to be 50 to 60% of the maximum heart rate of the subjects, the subjects swam distances of 25 meters until exhaustion. Blood samples were collected before the start of the training session and after the recovery phase. ANOVA with repeated measures was used to analyze the data. All statistical operations were performed using SPSS software version 16 and the significance level was considered P <0.05.

The results of this study showed that there was no significant difference between female swimmers in the effect of two periods of active recovery 1: 3 and 1: 4 on serum hs-CRP (P=0.17) and IL-6 (P=0.24) response after one session of intense interval swimming to exhaustion.

Swimmers can use both 3-fold recovery times and 4-fold recovery times, and these two types of recovery was not significantly different in terms of affecting IL-6 and hs-CRP response.

The aim of this study was to determine the effect of 12-week high-intensity interval training on heart mass and expression of beta-catenin and glycogen synthase kinase-3-beta genes in myocardial tissue of male rats. Thirty male Wistar rats were randomized into three groups, including sham (n = 10), control (n = 10), and HIIT (n = 10). The experimental group underwent HIIT consisting of 2 - 8 repetitions of 4-min high-intensity intervals (85% - 90% peak speed) interspersed with low-intensity intervals (45% - 50% peak speed), performed five times/week over 12 weeks. Forty-eight hours after the last training session, animals’ hearts were removed. The gene expressions of beta-catenin and glycogen synthase kinase-3-beta were analyzed by the RT-PCR method. The independent t-test was used for statistical analysis (P < 0.05). The results showed that the body weight was significantly lower in HIIT group (P = 0.029) and heart/body weight ratio were significantly higher in the intervention group than in the control group (P = 0.001). Also, beta-catenin gene expression were significantly higher in trained rats than the control group (P = 0.002). Regarding GSK3-β genes expression, although mean levels were lower in the trained group than the control, the differences were statistically insignificant (P = 0.71). HIIT training, along with considerable reduction of body weight, increase the ratio of heart to body weight and cardiac hypertrophy. Also, these exercise training trigger cardiac hypertrophic signals by stimulating the Wnt signaling pathway and significantly increasing beta-catenin gene expression.

Aging is associated with neurodegenerative and psychological disorders. Considering the ambiguity in the interactive effect of exercise and antioxidants, the aim of this study was to investigate the psycho-physiological effects of high intensity interval training (HIIT) and vitamin E (VE) in elderly trimethyltin (TMT)-treated Alzheimer's rats. In this experimental study, 50 Alzheimer's rats (age 18-22 months; weight 280-320 grams) induced by 10 mg/kg TMT were divided into five groups, including: (1) TMT, (2) sham/ vitamin E solvent, (3) VE, (4) HIIT (90-95% of the maximum speed) and (5) HIIT+VE. Ten healthy rats were included in the healthy control (HC) group to investigate the effect of TMT on research variables. HIIT was performed for eight weeks, three sessions per week, and VE was given orally to the rats at a dose of 30 mg/kg. In the HIIT and HIIT+VE groups, anthropometric indicators, food intake, anxiety and depression were significantly lower, and aerobic capacity, movement balance, and pain tolerance threshold were higher than the TMT group (P≥0.05). In the VE group, visceral fat weight, food intake, anxiety and depression were significantly lower than the TMT group (P≥0.05). Aerobic capacity was significantly higher in HIIT and HIIT+VE groups, and anxiety and depression were significantly lower than in the VE group (P≥0.05). It seems that HIIT, VE and HIIT + VE improve the weight, BMI and FW and physical and psychological performance, but the effects of HIIT on physical and psychological performance are much stronger than the effect of VE.

physical activity can play a supportive role in breast cancer improvement by regulating and modulating cytokines. Interleukin 10 is an anti-inflammatory cytokine that plays an important role in preventing the growth and metastasis of breast cancer, and interleukin 4 is an inflammatory cytokine that causes the growth and development of cancer cells. The present study was conducted with the aim of investigating the effect of 12 weeks of Pilates exercises on the serum levels of interleukin 4 and interleukin 10 in women with breast cancer.

The present study was conducted in a semi-experimental manner with two experimental and control groups on 30 women with breast cancer. The experimental group was given Pilates exercises for 12 weeks and 3 sessions each week for 60 minutes, while the control group did not participate in any physical activity. Blood samples were taken 48 hours before and after exercise intervention to measure interleukin 4 and 10 variables.

Based on the results of the correlated t test, the serum level of interleukin 10 in the experimental group increased significantly compared to the control group (P=0.001), and the amount of interleukin 4 in the experimental group showed a significant decrease compared to the control group(P=0.001).

Performing Pilates exercises with the benefit of anti-inflammatory cytokines and reducing inflammatory cytokines improves the health status of women with breast cancer. Therefore, doing exercises can help patients as a therapeutic factor. 

The aim of the present study was to investigate the effect of MCT1 A1470T polymorphism (rs 1049434) on one repetition maximum muscle strength in young athletes of the speed and endurance strength group in the chest press and squat-smith tests.

49 young trained male athletes with average age (24.22±5.54 years), height (178.57±8.91 cm), and weight (75.32±13.31 kg) were included in this research with the entry criteria. Muscle strength was calculated during one session using a maximum repetition test in two parts of the upper body (chest press test) and lower body (squats) for each subject. ARMS-PCR method was used to determine the genotype of the samples.

The results showed that there is a significant difference between the genotypes of the MCT1 polymorphism in one repetition of the maximum muscle strength of the Scott-Smith test in athletes (F=51.3, p=0.038) that the TT genotype with the highest strength in the test Scott Smith was with him. LSD post hoc test showed that subjects with genotype (TT+AT) have more strength compared to subjects with genotype (AA+AT). In the strength group between genotypes (AA and TT) in one repetition of maximum Scott-Smith muscle strength, the difference It was significant (p=0.047, F=3.54) and people with TT genotype had the highest strength in the Scott-Smith test.

The TT genotype of the MCT1 polymorphism has been associated with the lower body muscle strength of athletes and the effect of this genotype was evident in the athletes of the strength group.

Alzheimer's disease is a neurodegenerative disease. In this disease, the accumulation of beta-amyloid plaques in the brain causes a decrease in nerve density and the volume of the hippocampus. Studying the types of sports activities and finding the best type is considered as a way to control Alzheimer's. The aim of the current research was to study the effect of six weeks of continuous aerobic training on the neuronal density of the hippocampus CA1 region and memory performance.The current research was carried out experimentally. The statistical population was male Wistar rats with a weight range of 300 to 350 grams. For this purpose, 40 11-month-old male rats were prepared and randomly divided into four groups of 10 including the training patient group, control patient group, healthy training group and healthy control group. The rats performed the relevant exercises for six weeks by repeating five sessions per week. 48 hours after the last session, brain tissue was removed and data were collected. Neuronal density was measured by histological method and memory performance by novel object recognition test. The results were extracted using two-way variance analysis at a significance level of p≥0.05.Neuron density in the hippocampus in the training patient group increased significantly compared to the control patient group. Also, improvement of memory performance was observed in the training patient group compared to the control patient group (p=0.004). Performing continuous aerobic exercises for six weeks increases the neuronal density in the hippocampus and improves memory function in Alzheimer's disease.

Changes in adipokines levels play an important role in the development of different disorders including the type 2 diabetes, which among them, chemerin and omentin-1 attracted a lotof attention. In contrast, positive effect of exercise training and vitaminD consumption have been reported in combating with pathologic effects of type 2 diabetes. The aim of present study is to determine the effect of eight weeks resistance training along withvitaminD consumption on levels of chemerin and omentin-1 in type 2 diabetic patients

40 diabetics men with average age of 47.19±3.83 years old and body fat percentage 30.96±2.49 assigned in four groups including the placebo, vitaminD, training and training+ vitaminD groups. The resistance training program conducted for eight weeks and three session per week with 60 to 70 percent of 1RM intensity. VitaminD consumption considered daily 2000 iu and placebo (oral paraffin) ingestion considered in the same amount. At the baseline and ending intervention, blood samples collected and the levels of chemerin and omentin-1 were measured and insulin resistance calculated. Data were analyzed by analysis of covariance test and Bonferroni post-hoc test.

The present study findings indicated that in training and training+vitaminD groups the chemerin levels significantly decreased and omentin-1 significantly increased (p<0.05). Moreover, significant decrease of insulin resistance was observed in training and training+vitaminD groups (p<0.05).

VitaminD ingestion can increase the hypoglycemic effects of resistance training partly, which these positive effects of resistance training and vitaminD consumption exerted by increase in omentin1 levels and decrease of chemerin levels.

Exercise and supplementation prevent the dysfunction of BDNFand disorder in the serum levels ofCRPandIL-6caused by diabetes.The purpose of the study wasto determine the simultaneous effect of2months of combined training and taurine supplementation onBDNF,CRPandIL-6indices in diabetic rats.In this experimental study.30 adult male Wistar rats(250-300 grams and aged six weeks)were randomly divided into three groups diabetic exercisesupplementation(n=10),diabetic control(n=10)and healthy control(n=10).At the end of the8weekold,the amount of 55 mg/kg of body weight of streptozocin(STZ)was injected intraperitoneally,to make diabetic.The diabetic exercise-supplementation group performed the two months of combined exercises,5timesperweek(aerobic exercise with75%Vo2max on the treadmill and strength training includes15 times climbing the ladder).Taurine supplement was available to rats in the form ofa1%solution in daily drinking water(500 ml).The serum levels of BDNF,CRP and IL-6 were measured with Eliza method.OnewayANOVAand posthoc Tukey test were used to compare betweengroup and intragroup changes of BDNF,CRP,IL-6.The significance levelwasP<0.05.After two months of aerobicstrength training and taurine supplementation,BDNFserum level significantly increased in the diabetic exercise group compare to the diabetic group(P=0.003).Whereas,it significantly decreased in the diabetic control group compared to the healthy control(P=0.0001).CRPserumlevel significantly decreased in the diabetic exercise-supplementation group compare to the diabetic group(P=0.008).Whereas, it significantly increased the diabetic controlgroup compared to the healthy control(P=0.0001).After2months of aerobicstrength training and taurine supplementation there was no significant change inIL-6 serum level in the diabetic exercisesupplement group compared tothe diabetic control group andinthe diabetic control group compare to the healthy control(P=0.059).According to the findings ofthis research,2months of simultaneous aerobic-strength training and taurine supplementation are recommended to increaseBDNFlevels and reduce inflammationin diabetics.

exercise training has a remarkable metabolic and appetite-regulating effects. Appetite-regulating effects of exercise training may be altered by fasted and fed status.

in a randomized trial, 54 obese men with BMI > 30 kg/m2 were randomly divided into groups including 2 experimental groups of training (fasted and fed) and control. The experimental groups performed a concurrent exercise program including aerobic training (walking/ running at 60-70% of heart rate reserve lasting 30 minutes) followed by strength training (circuit training with 10 repetitions for each exercise in 3 rounds interspersed with 2-3 min rest) with a frequency of 3 d/w over 8 weeks. The fasted group performed exercise program following overnight fasting, and the fed group performed the exercise program following breakfast. At the beginning and 48 hours after the last training session measurements were performed. Data were analyzed using one-way analysis of variance at a significance level of 0.05.

concurrent training resulted in a significant decrease in leptin (p=0.001) as well as the appetite (p=0.002) compared to the control group; yet, no significant difference was observed between the two experimental groups (P<0.05). Furthermore, ghrelin significantly decreased in the experimental groups compared to the control (p=0.001) and a significant difference between the two experimental groups was also observed (p=0.013).

The findings of the present study indicates that appetite and leptin are remarkably affect by concurrent training but not by pre-exercise feeding status. However, ghrelin resting concentration is likely to be affect by pre-exercise feeding status (fasted vs fed).

The purpose of this present study was to investigate the effect of an interval training course on some inflammatory and anti-inflammatory factors of the heart tissue of rats with type 2 diabetes.

In this research, 60 male rats were selected and made diabetic with nicotinamide and streptozocin (STZ), and then randomly divided into 6 groups of 10: control, intermittent exercise, sham, intermittent exercise + saline, diabetic and diabetes + interval training were divided. The rats in the training groups performed an interval training program using a treadmill for 6 weeks and 5 days a week. Data analysis was done with one-way analysis of variance significant P≤0.05.

The results of this research showed that the levels of blood glucose, TNF-α and CRP in the intermittent exercise and diabetes+interval exercise groups had a significant decrease compared to the control and diabetes groups (P=0.001, P=0.001 and P=0.003 respectively). P) and insulin resistance index did not change significantly (P=0.21). Also, the amount of IL-10 in the intermittent exercise and diabetes+intermittent exercise groups had a significant increase compared to the control and diabetes groups, respectively (P=0.01).

The results of this study showed that interval training can be used as a therapeutic strategy to reduce the inflammatory factors TNF-α and CRP and increase the anti-inflammatory factor IL-10 in heart tissue of type 2 diabetic patients.