Asian Journal of Nanoscience and Materials
Volume:4 Issue: 1, Jan 2021

Optical, electrical, and electronic properties of materials are essential in the fabrication of electronic devices. These properties can be improved through doping and reduction of the size of a material to nanoscale. In this study, copper doped magnesium-nickel (CuxMg1-xNiFe2O4, for x=0.00, 0.15, 0.30, 0.45, 0.60, 0.75, 1.00) ferrite nanoparticles were synthesized using the citra-gel auto combustion method. The electronic and optical properties were evaluated using the scanning Kelvin probe microscopy (SKPM) and UV-visible, respectively. The UV-visible studies revealed that, the band gap energy was at the range of 3.600-3.750 eV. The band gap was noted to increase with copper content up to x=0.45 which then started to decrease. The undoped sample displayed the lowest band gap energy in comparison with the doped. SKPM analysis exhibited the surface potential in the range 4.361-5.002 eV for the area scan and 4.251-5.006 eV for the line scans for the samples. The sample with x=0.75 showed a positive work function for both area and line scans, and all the others had a negative work function. The doped ferrite exhibited the properties that could be applied in optical devices, storage devices, and recording devices.

Single-walled carbon nanotubes (SWCNTs) have been widely utilized in many types of applications, cinfirming their excellent role as carriers of drugs with a highly site-selective delivery capability. As nanotubes can release drugs into the tissue cells without damaging the healthy cells, it is necessary to determine the structural properties of drugs–SWCNTs complexes which may lead to the development of optimal SWCNTs as new effective drug transporters. In this work, a theoretical study of structural properties and reactivity of clopidogrel drug with C (5, 5) carbon nanotubes is presented. Computational and chemical simulations were carried out for clopidogrel, SWCNT and clopidogrel-SWCNT by B3LYP/6-31+G with the Gaussian 09 program and then energies of all optimized configurations were evaluated by the M06-2X density functional method. The highest occupied molecular orbital (HOMO), lowest unoccupied molecular orbital (LUMO), natural bond orbital (NBO), global reactivity descriptors and density of states (DOS) of clopidogrel and SWCNT were calculated. The results show that there is a relationship between the energy gap and the DOS. The nature of interaction and bonding between the clopidogrel and SWCNT is physisorption as the adsorption energy and charge transfer is small, and adsorption distance is large. Generally, the results of our simulation studies demonstrated that, the carbon nanotubes have a high potential to be considered as carriers of clopidogrel in drug delivery systems. Band gaps of clopidogrel-SWCNT complex, which were computed by B3LYP method, are 1.777 and 1.860 eV in gas and the solution phases, respectively. Also, the dipole moment of clopidogrel-SWCNT complex in solution phase is 5.286 Debye, which is higher than the gas phase (3.234 Debye). These results show the effect of the solvent on the complex.

In this research study, a library of highly substituted imidazoles were efficiently synthesized from benzil/benzoin, aldehydes and ammonium acetate via multicomponent solvent free one pot protocol on TiCl3-silica solid catalyst. The general applicability of the solid support was assessed by the synthesis of wide varieties of imidazole derivatives. TiCl3-silica solid catalyst was recycled, reused and found no loss of catalytic activity up to fifth consecutive reaction runs.

In this research study, NiO nanoparticle (NiO-NPs) was synthesis using a simple strategy method (chemical precipitation), then it was utilized for amplification of paste electrode (PE) at the presence of paraffin oil and 1-hexyl-3-methylimidazolium hexafluorophosphate (HPF6). NiO nanoparticle was characterized using the transmission electron microscopy (TEM) and energy-dispersive X-ray spectroscopy (EDS) method. The NiO-NPs/HPF6/PE was used as electrochemical sensor for determination of epinephrine in pharmaceutical and urine samples. The sensor improved the oxidation signal of epinephrine about 2.87 times. The pH investigation confirmed that the electro-oxidation of epinephrine was relative to pH changing in the presence two electrons and two protons. The square wave voltammetric investigation showed that the oxidation current of epinephrine has linear relation with its concentration in the range 1.0 nM-300 µM with detection limit 0.5 nM.

< p>< p>We present a report regarding the cytotoxic effects of iron-based magnetic nanoparticles conjugated with fluorodeoxyglucose (FDG-mNPs) on the viability of NCI-H727 and SH-SY5Y cancer cells. MTT assays were performed to determine cell viability in treated cancer cells grown under standard 2D culture conditions. FDG-mNP concentrations of 0.075 mg/mL, 0.15 mg/mL, and 0.3 mg/mL decreased mean cell viability of NCI-H727 cells to 92.5%, 82.9%, and 75% respectively. FDG-mNPs was also shown to have a detrimental effect on the viability of SY5Y cells: a decrease of 5.7%, 18.6%, and 36.4% was found for SY5Y cells treated with 0.075 mg/mL, 0.15 mg/mL, and 0.3 mg/mL concentrations of FDG-mNPs, respectively. When NCI-H727 and SH-SY5Y cancer cells were grown as 3D spheroids, morphology was visibly changed and the number of viable cells was decerased in spheroids treated with FDG-mNPs compared with untreated spheroids. The results of our study demonstrated that FDG-mNP has toxic effects on NCI-H7272 and SY5Y cancer cells, and we conclude that conjugated FDG-mNPs are promising in the development of clinical applications for the destruction of cancer cells.

The purpose of this research study was to assess the use of nanoparticles in combat pathogenic microorganisms and also to investigate the synergistic effect of nanoparticles with antibiotics in eliminating these factors. In this work, the influence of different nanoparticles on microorganisms was evaluated in 89 studies. It was found that nanoparticles can be used against microorganisms, either independently or by their synergistic effect with antibiotics. The study found that metal nanoparticles have a more anti-microbial effect, among metal nanoparticles, silver nanoparticles exert the most specific among all microorganisms. Meanwhile, metal nanoparticles can be a good alternative to the use of antibiotics and inhibitors of pathogens.

In this work, 1-methyl imidazole-based ionic liquid stabilized on silica coated Fe3O4 magnetic nanoparticles [nano-Fe3O4@SiO2@(CH2)3-1-methyl imidazole]HSO4 as a new, efficient, and magnetic Brønsted acid nano-magnetic catalyst was synthesized and characterized using various techniques including, Fourier transform infrared spectrometer (FT-IR), scanning electron microscopy (SEM), thermo gravimetric analysis (TGA), X-ray diffraction patterns (XRD), and vibrating sample magnetometry (VSM). Magnetic nanoparticles (MNPs) were used to synthesize thr 5-arylmethylene-pyrimidine-2, 4, 6-trione derivatives by the one-pot condensation reaction between barbituric acid and various aldehydes in water at reflux conditions. Similarly, 2-arylidenemalononitriles were synthesized by the one-pot of condensation reaction between various aldehydes and malononitrilein water as a green solvent at room temperature. This method has several advantages, such as short reaction times and high yields, non-using of toxic solvent, being eco-friendly benign, recyclability and reusability of the catalyst with external magnet for several time.