مجله دانشکده پزشکی اصفهان
پیاپی 762 (هفته دوم خرداد 1403)

Various exercises have been studied to reduce the complications caused by the use of doxorubicin and other chemotherapy drugs on healthy body organs; But a limited number of these studies have compared the effect of different sports programs; Therefore, the aim of this study is to compare running and swimming on some liver enzymes of rats induced by doxorubicin.

36 adult male desert mice weighing 230 to 280 grams were randomly divided into 6 groups of 6: resting sham (SH), treadmill sham (SHT), swimming sham (SHS), doxorubicin rest (D), doxorubicin treadmill (DT), doxorubicin swimming (DS) were divided. The sports groups did the exercise program 5 sessions a week for 6 weeks. 24 hours after the last exercise session, blood was taken from the left ventricle of the animal with a syringe. To analyze the data, descriptive analysis and one-way analysis of variance, ANOVA and Tukey's post hoc test at a significance level of 0.05.

Doxorubicin injection caused a significant increase in ALP, SGPT, and SGOT enzymes, both running and swimming exercises caused a significant decrease in ALP, SGPT, and SGOT enzymes, but there was no significant difference between the running and swimming groups on the reduction of the studied enzymes.

Based on the results of the present study, it seems that endurance sports activities are a good way to reduce hepatotoxicity caused by doxorubicin injection in cancer patients, and none of the swimming and running exercises are preferable to the other.

Bariatric surgeries are accompanied by problems such as gallstone formation following the rapid weight loss after the surgery. This retrospective cohort research intended to study the relationship between Ursodeoxycholic acid (UDCA) administration and prevention of gallstone formation after three types of bariatric surgery.

In this cohort study, 444 patients who underwent bariatric surgery in Al-Zahra and Sina Hospitals between March 2019 and August 2020 were divided into group A (UDCA-treated patients) and group B (untreated patients). The patients followed up six months after the surgery through gallbladder ultrasonography. In addition, Body mass index (BMI) values were recorded before and after the surgery. Data analysis was done using Chi-square and Poisson regression tests.

Half of the 444 patients (50%) received UDCA. The follow-up ultrasound showed that gallstones had formed in sixteen (7.2%) of the patients in group A and 45 (20.27%) in group B. There was an indirect relationship between the rapid decline of BMI and the formation of gallstones following bariatric surgery.

According to findings from this research, the patients who received a prophylactic dose of UDCA post-bariatric surgery in various doses showed lower gallstone formation than those who didn’t receive UDCA medication.

The serum level of vitamin D on preterm delivery has been investigated in a number of studies, and this relationship is still debatable. The present study was conducted to systematically review the studies conducted in the region of the relationship between serum levels of vitamin D in mothers and preterm delivery.

In this systematic review to find related studies, the English databases PubMed, Google Scholar, Web of Science, SID, and Magiran, which were published from 2015 to 2023. The quality of the articles was assessed using the Newcastle-Ottawa checklist.

A qualitative evaluation of the remaining 55 articles was performed after reviewing the title, abstract, and text. Finally, 9 articles were included in the systematic review. According to the results of the studies, there is a relationship between the serum level of vitamin D and premature birth.

Low serum levels of vitamin D are significantly associated with an increased risk of preterm delivery.