جستجوی مقالات مرتبط با کلیدواژه « Autism » در نشریات گروه « زیست شناسی »

autism spectrum disorders (ASD) represent a heterogeneous group of neurodevelopmental syndromes that are clinically characterized by deficits in social interactionand repetitive behaviors . The pathogenesis of ASD is complex and not fully disclosed. Vitamin E is a fat-soluble vitamin that has strong antioxidant activity. Previous studies have reported decreased plasma levels of vitamin E in autism spectrum patients and beneift effect of prenatal treatment . The present study was conducted to investigate the effect of two week postnatal treatment of vitamin E on autism-like behavior in rats exposed to VPA.

pregnant rats were divided into two groups from the 14th day of pregnancy, one group received only normal food and water, and the other group was injected with valproic sodium on the 14th day of pregnancy. The offspring were tested for repetitive behaviors and cognitive ability with a T-maze task and social interaction with a play behavior task on 44st of Postnatal days

Administration of vitamin E in mice treated with VPA increased cognitive flexibility compared to VPA treatment alone. Vitamin E treatment of mice treated with VPA led to the improved social behavior of pinning with strange mice . Administration of vitamin E in VPA-treated mice did not improve any of the social behaviors including sniffing, running, and grooming compared to valproic acid treatment alone

The findings of the present study showed that vitamin E treatment improves cognitive flexibility and to some extent social behaviors in autistic rats.

In people with autism, communication, social interaction, and imaginative games have been particularly damaged. Thiomersal, commonly called mertiolate, is an organo-mercury compound that has antifungal and antiseptic properties. In recent years, the relationship between the likelihood of autism caused by thiomersal vaccines has been significantly raised by the media.

The present study examined dose-dependent behavioral changes after early exposure to thiomersal in a timed pattern of vaccination of children in male rats. Newborn mice were injected with 300 micrograms of thiomersal on days 7, 9, 11, and 15. From day 31 to day 80 After birth different exercise protocols 1 and 2 were applied. Immediately, after the respective protocols, in less than 30 seconds, the brain was removed from the skull and the brain prefrontal was rapidly exited. Finally, genes expression of ATG8 and ATG10 in the prefrontal l region were evaluated by Western blotting technique.

The results showed that the mice of receiving the thiomersal and did exercise protocols, especially the mice that did the 1 and 2 exercise protocol, had significantly lower ATG8 and ATG10 gene expression than the control group. Therefore, it can be concluded that mid-term exercise is effective in removing the adverse effects of thiomersal on the expression of autophagy genes.