جستجوی مقالات مرتبط با کلیدواژه « Artemisia absinthium L. » در نشریات گروه « پزشکی »

Diabetes is the most important metabolic disease in most societies and researchers are looking for drugs with fewer side effects to control diabetes. The aim of this study is to investigate the effect of the Artemisia absinthium L. extract on blood glucose levels in diabetic rats.

Methods and Materials: 

In this study,40 adults male Wistar rats weighing 200-250 g were selected and randomly divided into 5 groups of 8. The groups contain controls, healthy controls, diabetic controls, and diabetics treated with doses of 80 and 120 mg per kg body weight. Streptozotocin was injected intraperitoneally to induce diabetes. The experimental groups were treated orally with the Artemisia absinthium L. extract for three weeks and then the serum glucose sample of the animals and the initial and final weight of mice in all groups were measured. The obtained data were statistically analyzed by SPSS statistical software.

The results showed that the blood glucose level in the groups treated with the extract significantly decreased compared to the diabetic control group. Also, a comparison of the therapeutic effects of the Artemisia absinthium L extract in diabetic rats shows that in high doses of the extract, it had more effects in lowering blood glucose. Weight gain was also observed in all groups treated with the Artemisia absinthium L extract.

It seems that the Artemisia absinthium L extract has a blood glucose-lowering effect due to the presence of flavonoid compounds and polyphenols.

Production of anti-Toxoplasma drug with high efficacy and low side effect is one of the main priorities in toxoplasmosis researches. Herbal extracts has considered as a candidate for this purpose.
This study was performed in order to determine lethal effect of Artemisia absinthium L., Carum copticum L. and Gossypium hirsutum extracts on Toxoplasma gondii tachyzoites in vitro free cell line.
Tachyzoites of T. gondii RH strain were treated with concentrations of 10, 50, 100, and 200 mg/ml of Artemisia absinthium L., Carum copticum L., and Gossypium hirsutum extracts within 10, 30, and 45 min. Afterward, the tachyzoites were stained with alkaline methylene blue. Mortality rates of tachyzoites treated with extracts were determined. The results were analyzed with one way ANOVA and Post Hoc Test by SPSS software. P The overall, 100% of tachyzoites were killed at concentrations of 50, 100, and 200 mg/ml of Artemisia absinthium L. and 200 mg/ml of Carum copticum L. after 10, 30, and 45 min treatment. The lowest mortality rates at concentration of 10 mg/ml were 19.6±8.4, 4.30±2.26, and 4.63±2.1 for Artemisia absinthium L., Carum copticum L., and Gossypium hirsutum, respectively. The highest and lowest mortality rate of tachyzoites by Gossypium hirsutumin extract was 13.3 ±7.1. The mortality of tachyzoites were confirmed by bioassay in mice.
Anti-Toxoplasma activities of Artemisia absinthium L. and Carum copticum L. were significantly higher than Gossypium hirsutum. Further studies in order to clarify effectors are recommended.

Background and Dispersion of absinthium in Iran: Mazandaran, Gilan, Azerbaijan, Kurdistan, Tehran and Khorasan. In sources of traditional medicine, absinthium is used for treathment of many diseases. This is achieved by reviewing the references of Iranian traditional medicine as well as the observations cited in recent scientific evidence, and carrying out comparative evaluation of these items.
Material and the present study has been an overview study and has been codificated by Library search in the main source of Traditional Persian Medicine and adjastment them with modern articles and medicine.
It has been observed the antioxidant activity, hepatoprotective, anthelmintic effect, anti malaria, neuroprotective, antiepileptic, antiparasitic, anti-snake venom and anticancer activity from Artemisia absinthium L. In practical survey. Phytochemical analyses revealed the presence of sesquiterpene lactones, flavonoids, phenolic acids, tannins, essential oils, resin, lactons and Organic acids in extract of Artemisia absinthium L..
this show the very close adjustment between the practical finding carried on Artemisia absinthium L. and source of Traditional Persian Medicine. Thus we can Produce medicinal products for treatment many kind of diseases by more careful study in the ancients texts and use of scientific new finding of this plant.