A Case Report of Manic Episode in A Patient with Neuronal Migration Anomaly

Neuronal migration disorders of the brain cortex are a diverse group of brain abnormalities with different etiologies and entities. They may present with various neurological and ocular abnormalities, while psychiatric presentation is very rarely reported. Here we described the first case of mania in a patient whit neuronal migration disorders. Case history: we report a 27 – year – old male with symptoms of mania with a prior history of occasional seizure attacks whose MRI showed neuronal migration disorder and his symptoms was controlled with sodium valproate. Association between neuronal migration disorders and mania was shown in this case. Besides, it raises the possibility that, as shown by other researchers, there may be common basis between mood disorder and neuronal migration disorders.