Evaluation of the relationship between platelet count, mean platelet volume and pulmonary thromboembolism

Mean platelet volume (MPV) is associated with platelet reactivity. Large platelets contain more thrombogenic factors than small ones. Previous studies have shown platelet reactivity in patients with pulmonary thromboembolism (PTE).The aim of this study was to investigate the mean platelet volume (MPV) and platelet count in patients with PTE and healthy control subjects.

In This study, 210 patients with PTE were retrospectively evaluated. The diagnosis of PTE was made clinically and was confirmed with CT angiography. 210 healthy subjects matched for age, gender and body mass index (BMI) served as control group. We recorded the main demographic, clinical and laboratory data of groups. MPV values and platelet counts were measured at the first day of admission.

Mean age between PTE patient and control group was 52.6 ± 19.7 vs. 49.43 ± 20.68 years respectively (p=0.109). MPV was significantly higher among patients with PTE in comparison with control group (10.57 ± 1.08 vs. 9.80 ± 0.86 fL respectively; p= 0.000). Platelet count was not significantly different in PTE patients and control group (231.76 ± 92.22 vs. 243.76 ± 67.32 × 10 9 /L, respectively; p= 0.129).

MPV is a simple and easy test and it can be used as an activity marker of platelet function in PTE. It also shows the platelet production rate and stimulation. We have shown that MPV was increased in patients with PTE. Platelet count was not different between PTE patients and control group.