Role of Epsilon Aminocaproic acid & Tranexamic Acid, vs Placebo in Reduction of mediastinal Bleeding following Open Heart Surgery

Author(s):

Ghavidel Aa. , Jalilifar N. , Sharifi M. , Ghasemzadeh B. , Alinejad Z. , Ghafarinejad Mh. , Khamushi A. , Bakhshande H. , Hosseini S. , Farsad F. , Yousefnia Ma

Message:
Abstract:
Background
Post-operative bleeding is one of the Challenging issues in cardiacsurgery. The Excessive bleeding and need for transfusion of blood products may increases the patients’ mortality and morbidity. Although use of antifibrinolytics has long been the issue of interest but recently according to some reports of sudden death after use of aprotinin has encountered great limitations. So we decided to find an alternative drug for aprotinin. Methods and Materials: This study was performed as a Double blind Randomized clinical traial. Three hundred patients underwent open heart surgery using CPB to Shahid Rajaee Heart Center. The patients were divided into 3 groups; each containing 100 patients. Group A Amicar (Caproamin), group B (Tranexamic acid) and group C (Control). The mean age was 56.5 yr. (Ranged 16-79). 65.3% were male and 85.7% underwent CABG. Need for blood and blood products transfusion in operating room, ICU & ward, as well ad post-op drainage volume during 6, 12, 24 hours were evaluated. The probable post-op complications including post-op myocardial infarction or CNS, renal complications were also recorded
Language:
English
Published:
Multidisciplinary Cardiovascular Annals, Volume:2 Issue: 4, Aug 2009
Page:
13
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