Effects of Zingiber officinale Roscoe Extract on Spermatogenesis and Hormonal axis of Pituitary Gonad in Immature Balb/C mice

Ginger is one of the most valuable medical plants. It is a plant that contains most anti oxidant such as B, C and E vitamins and this plant is effective in sexual ability. In this research, the effect of ginger extract has been investigated on hormonal axis of hypophysis-gonad and spermatogenesis in immature mice of Balb/C. The used animals were 28 male mice with approximate weight about 15 to 18 grams and with the age about 25 to 30 days. The samples randomly were divided in to 4 groups that are contained control and sham and two treatment groups. Treatment animals, received 50 and 100 mg/kg of mentioned extracts respectively two weeks, intraperitoneally. During mentioned period, sham group received distilled water in intrapritoneally. Control group used of food and drinking water. The concentration of LH hormone serum levels showed significant decrease in treatment2 group and the concentration of FSH hormone also in each two treatment groups in comparison with control and sham groups. The concentration of testosterone hormone indicated significant increase (p<0/05) in treatment2 group in comparison with control and sham groups. Also results indicated that the number of spermatid and sperm cells have significant increase in treatment groups in comparison with control and sham groups. Also results indicated that the number of spermatocyte and leydig cells in treatment group indicated significant increase (p <0/05) as comparision with control and sham groups. So, according to obtained results, with increasing of the number of leydig cells and testosterone concentration, it can concluded that ginger may causes proliferation of sex cell in immature male mice.